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RecruitingPhase 2

Effects of an Antioxidant Supplement on Blood Vessel Health

Role of Mitochondria-derived Oxidative Stress on Microvascular Endothelial Function in Healthy Non-Hispanic Black and White Adults

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 75 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests an antioxidant supplement and its effects on blood vessel health in healthy non-Hispanic Black and White adults ages 18–75. It looks at whether mitochondria, the parts of cells that make energy, cause cell stress that harms blood vessels in Black adults.

Cardiovascular disease (CVD) is a leading cause of morbidity and mortality worldwide, and the non-Hispanic Black (NHB) population is disproportionately affected. Our research has previously demonstrated that oxidative stress may contribute to reduced vascular function in otherwise healthy NHB adults, potentially predisposing them to the development of hypertension and CVD. This study is designed to examine whether the mitochondria are an important source of oxidative stress-induced vascular dysfunction in healthy NHB adults.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Identify as non-Hispanic Black or non-Hispanic White.
  • Be a man or woman age 18–75.
  • Have blood pressure below 130 for the top number and below 85 for the bottom number.
  • Have LDL (“bad”) cholesterol below 150 mg/dL.
  • Have an HbA1c below 6.0%. This blood test measures average blood sugar.

Who can't join

  • Have a rash, skin disease, or changes in skin color, such as psoriasis, eczema, or vitiligo; or have a known skin allergy to latex or adhesives.
  • Have smoked or used nicotine products in the past year, or use illegal or recreational drugs.
  • Have kidney disease or a history of skin cancer or any other cancer.
  • Take chloramphenicol, cholestyramine, seizure medicine, methotrexate, nitrofurantoin, tetracycline, barbiturates, steroids, phenobarbital/phenytoin, orlistat, or pyrimethamine.
  • Take any medicine that could affect how the heart or blood vessels work or respond.
  • Have known or suspected heart or blood vessel disease, a disease affecting how the body uses food for energy, or diabetes (HbA1c of 6.0% or higher).
  • Are pregnant or breastfeeding.
  • Have narcolepsy, a condition that causes strong daytime sleepiness, or a diagnosed condition that makes it hard for the body to control its temperature.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Self-identify as either non-Hispanic Black or non-Hispanic White. * Men and women 18-75 years old. * Non-hypertensive (systolic blood pressure \[SBP\]\<130 and diastolic blood pressure \[DBP\] \<85 mmHg). * Have low density lipoprotein cholesterol \<150mg/dl. * Have HbA1C \<6.0%. Exclusion Criteria: * Rash, skin disease, or disorders of pigmentation (e.g., psoriasis, eczema, vitiligo, or other skin inflammatory skin disorders) * Known skin allergies to latex or adhesives * Smoking and/or use of nicotine-containing products within the past year * Use of illegal/recreational drugs * Generalized kidney disease * Taking chloramphenicol, cholestyramine, medication for seizures, methotrexate, nitrofurantoin, tetracycline, barbiturates, steroids, phenobarbital/phenytoin, orlistat or pyrimethamine * Any current medications which could conceivably alter the cardiovascular control or responses * Diagnosed or suspected metabolic or cardiovascular disease * Current pregnancy or breastfeeding * History of skin or other cancers * Diagnosed or suspected diabetes (HbA1c ≥6.0) * Anybody with narcolepsy or who has been diagnosed with any condition that impairs body temperature regulation.

Study sites (1)

GA