RightFit
RecruitingNot applicable

Exercise, Brain Activity, and Weight Maintenance

Effects of Exercise Training on Brain Activity and Its Relation to Weight Maintenance and Appetite Regulation

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 70 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Visits mentioned: 3 visits
  • Procedures mentioned: Blood draws, MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will complete three initial clinical visits before beginning a 12-week high-intensity interval training (HIIT) program, followed by three post-training clinical visits."
  • "During visit 1, participants will undergo anthropometric assessments, baseline blood draw, oral glucose tolerance test, psychometric evaluations, and complete an MRI safety screening."
  • "During visit 3, participants will have another baseline blood draw and undergo a functional MRI (fMRI)."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

This study aims to explore how HIIT influences brain function, neural and molecular pathways related to weight control, setting the stage for future obesity intervention research.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Age 18-70 years * Body mass index (BMI) \>19 kg/m2 and body weight\< 250kg * Participants must have experienced a clinically significant weight regain, defined as over 10% of their maximum weight lost, within 1 to 5 years following their bariatric surgery. They will be asked to self-report their weight loss history. Participants must also provide the operative report from their bariatric surgery for reference. * In good general health with no conditions that could influence the outcome of the trial, and in the judgment of the investigator is a good candidate for the study based on review of available medical history, physical examination and clinical laboratory evaluations * Willing to adhere to the protocol requirements for the duration of the study Exclusion Criteria: * Type 1 diabetes mellitus * Peripheral neuropathy with insensate feet * Recent blood donation within the last 2 months * Use of beta-blockers * Current pregnancy or breastfeeding * Active Heart or lung disease * Severe hypertension (systolic \>160 mmHg or diastolic \>90 mmHg) * Inability to exercise for any reason * Any known contraindication to exercise testing based on current ACSM guidelines * MRI contraindications, such as presence of pacemakers, aneurysm clips, artificial heart valves, ear implants, metal fragments, or foreign objects in the eyes, skin, or body * Known presence of a structural brain lesion (e.g. tumor, cortical infarct) * Presence of another neurologic disorder, which could impact findings (e.g. multiple sclerosis) * History of cardiovascular disease, stroke, congestive heart failure * Active hematological, renal, pulmonary or hepatic disorders * Active treatment for cancer * A history of active alcohol or substance abuse * Any significant systemic illness or unstable medical condition which could lead to difficulty complying with the study protocol * History of claustrophobia and inability to tolerate an MRI * Body weight \>250kgr and largest body diameter of 70cm as there is a certain weight and diameter limit of the MRI scanner * Unwilling or unable to return for study visits, undergo neuropsychological testing and MRI imaging * Left-handedness

Study sites (1)

MA