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Attenuating DEPression With Internet CBT to Slow Cognitive Decline in Older ICU Survivors(ADEPT-ICU)

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
50 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests Good Days Ahead, an online cognitive behavioral therapy (CBT) program that helps people work on thoughts and behaviors. It looks at whether the program reduces reported memory and thinking problems in adults age 50 and older who have depression symptoms after a stay in the intensive care unit (ICU).

Depression affects one-third of intensive care unit (ICU) survivors and represents a potentially modifiable target to slow cognitive decline and reduce the risk of Alzheimer's disease and related dementias (ADRD). Our multi-PI team proposes a two-arm RCT called ADEPT-ICU (Attenuating DEPression with Internet CBT to Slow Cognitive Decline in Older ICU Survivors), which will test the efficacy of an internet CBT intervention called Good Days Ahead (GDA) to reduce the burden of subjective cognitive decline (SCD) in older ICU survivors with moderate to severe depressive symptoms after ICU hospitalization.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are age 50 or older.
  • You stayed in the ICU for more than 48 hours.
  • You can understand the study and agree to take part.
  • Your depression screening score is 10 or higher, or 5–9 with low mood or loss of interest or pleasure.
  • You are willing to take memory and thinking tests.
  • You have access to a telephone.
  • You leave the hospital for home, independent living, or assisted living.
  • You report trouble concentrating on the depression screening, report a change in memory or thinking in the past 1–3 years, or score in the lowest 25% on a thinking test compared with similar people.

Who can't join

  • You have dementia or a disease that damages the brain over time, such as Parkinson’s disease, or took dementia medicine before your ICU stay.
  • You have bipolar disorder, schizophrenia, or schizoaffective disorder, or ongoing trouble knowing what is real after your ICU stay that would keep you from completing the program.
  • You have a recent or repeated alcohol or drug use disorder.
  • You are expected to live less than 1 year.
  • You had a stroke, brain injury, or brain surgery before, during, or after your ICU stay.
  • You have vision or hearing loss that has not been corrected, including legal blindness or deafness.
  • You have had a tracheostomy, an opening in the neck to help you breathe, and cannot communicate.
  • You are in jail or prison, or on parole, after your ICU stay.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria 1. 50 years of age and older 2. Admitted to the intensive care for greater \> 48 hours 3. Able to understand and provide informed consent 4. Elevated depressive symptoms, defined as Screening PHQ-9 or PHQ-8 ≥ 10 or Screening PHQ-9 or PHQ-8 = 5-9 with the presence a core symptom of anhedonia (PHQ-9 or PHQ-8 Item 1) or depressed mood (PHQ-9 or PHQ-8 Item 2) 5. Willing to participate in cognitive testing 6. Access to a telephone 7. Discharge to home or an independent or assisted living facility 8. Response is a 1,2, or 3 on PHQ-9 or PHQ-8 item 7, answered yes to "Have you experienced a change in your memory or other aspect of thinking in the past 1 to 3 years?", or score in the 25% percentile or lower on the Montreal Cognitive Assessment (MOCA) based on normative data which account for age, gender, race, ethnicity and education. Exclusion Criteria: 1. Diagnosis of dementia or neurodegenerative disease (e.g. Alzheimer's disease, vascular dementia as per EHR and IQCODE, or Parkinson's disease) or on anti-dementia medications prior to ICU stay 2. Diagnosis of severe mental illness (bipolar disorder, schizophrenia, schizoaffective) as per EHR and screening questions 3. Persistent psychotic symptoms after ICU stay which would interfere with successful completion of intervention 4. Recent or recurrent alcohol or substance use disorder as per HER and Drug Abuse Screening Test 5. Life expectancy less than 1 year (e.g. terminal cancer diagnosis, discharged on hospice) 6. Ischemic or hemorrhagic stroke, traumatic brain injury, or undergoing neurosurgery prior, during or after ICU stay 7. Uncorrected visual or auditory impairment including legal blindness or deaf 8. Status post tracheostomy and not able to communicate 9. Incarcerated or on parole after ICU stay

Study sites (2)

IN