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How a Single Workout Affects Gut Bugs in Women With Different Fitness Levels and Body Types

The Acute Effects of an Endurance Exercise Bout the Gut Microbiome and Gut-derived Metabolome in Women's Distinct Fitness and Body Mass Indexes

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
21 Years to 40 Years
Sex
Female only
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Blood draws

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Potential discomforts associated with a blood draw are bruising and possible infections."
  • "Ongoing monitoring and reporting of any adverse effects will be maintained Blood collection: The blood collection will take place at the GW Metabolic and Exercise Testing Laboratory (METLAB) and will be performed using aseptic techniques by a trained phlebotomist to minimize any ill effects from all blood draws."
  • "Participants will be monitored for potential side effects of blood draws, including dizziness, lightheadedness, and nausea."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

This study aims to elucidate the differences in the gut microbiome functional activity and metabolome in adult premenopausal women with distinctive fitness levels and BMIs (with obesity, w/o obesity). The specific aims are as follows: * Aim 1: To examine the effects of acute aerobic exercise at 60-70% heart rate reserve (HRRmax) for 30 minutes bout on changes in the abundance of SCFA-producing bacteria and their functional downstream metabolic activity. * Aim 2: To examine the effects of acute aerobic exercise at 60-70% HRRmax 30-minute bout on changes in GM-released SCFA concentrations in stool and plasmatic metabolome.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Biological sex: female * BMI 19 to 24.99 kg/m2 or BMI 30-40 kg/m2 * Exercisers: Exercise at least 4 times per week for 60 minutes (a total of 240 minutes per week) on a programmed exercise training either on endurance sports (e.g., running, cycling, triathlon), strength (e.g., powerlifting), or team sports (e.g., rugby, football, soccer) * Non-Exercisers: Sedentary individuals who have not reached the PA guidelines (150 minutes of moderate-intensity physical activity a week, 75 minutes of vigorous-intensity physical activity, or an equivalent combination of moderate and vigorous-intensity physical activity). Exclusion Criteria: * Biological sex: male * BMI \< 19 kg/m2 or \> 40 kg/m2 * Currently pregnant, \< 2 years postpartum, lactating * Currently taking any herbal, fiber, or prebiotic supplement * Current or 1-month before the study, taking oral or vaginal antibiotics * Diagnosed with any gastrointestinal, endocrine, digestive, cancer, or cardiovascular disease.

Study sites (1)

DC