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Safe and Explainable AI

SAFE AND EXPLAINABLE AI-ENABLED DECISION MAKING FOR PERSONALIZED CLINICAL DECISION SUPPORT

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study aims to make medical artificial intelligence (AI) safer, better at using medical knowledge, and easier for doctors to understand. It uses patient data from adults in Penn Medicine heart care, sepsis care, and breast cancer groups. Sepsis is a dangerous reaction to an infection.

While current AI technology is suitable for automating some repetitive clinical tasks, technical challenges remain in solving critical and gainful problems in the domains of patient and disease management. The proposed research seeks to address issues in medical AI, such as integrating medical knowledge effectively, making AI recommendations explainable to clinicians, and establishing safety guarantees.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Heart care group: Adults age 18 or older admitted to any Penn Medicine hospital from 2017 to the present.
  • Sepsis group: Adults age 18 or older when seen in an emergency department or admitted to a Penn Medicine hospital on or after July 1, 2017.
  • Breast cancer group: Adults age 18 or older listed in the Penn Cancer registry with stage 1–4 invasive breast cancer. This is cancer that has grown into nearby breast tissue.

Who can't join

  • All groups: Patients under age 18 will not be included in the data used to build prediction models.
  • Heart care group: Patients admitted mainly because of cardiac arrest, when the heart suddenly stops pumping blood.
  • Sepsis group: Patients who already had limits on treatments used to keep them alive.
  • Breast cancer group: No other exclusions are listed.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: Cardiology 18 years of age and older, admitted to any of the Penn Medicine hospitals from 2017 to the present. Sepsis 18 years of age at the time of presentation to an emergency department or admission to any Penn Medicine hospital from July 1, 2017, onward will be eligible as this represents the population at risk for acquiring sepsis Oncology 18 years of age and older with a diagnosis of invasive breast cancer (Stage 1-4) in the Penn Cancer registry Exclusion Criteria All prediction models will exclude patients under the age of 18 from their patient data sets. Cardiology Patients whose primary admission diagnosis was cardiac arrest Sepsis Those with pre-existing limitations on life-sustaining therapy will be excluded because their eligibility for sepsis definitions, care received, and outcomes, may be significantly and variably affected by pre-existing limitations on care. Oncology There are no other exclusions.

Study sites (1)

PA