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Can Computational Measures of Task Performance Predict Psychiatric Symptoms and Changes in Symptom Severity Across Time

Leveraging Computationally Derived Measures of Individual Differences in Learning and Decision-making to Predict Psychiatric Diagnosis, Symptoms and Changes in Symptom Severity Across Time

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 65 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether computer-based measures of task performance can predict mental health symptoms and how they change over 12 months. It is for adults ages 18 to 65, both with and without certain mental health conditions.

This study investigates the computational mechanisms associated with psychiatric disease dimensions. The study will characterize the relationship between computational parameter estimates of task performance and psychiatric symptoms and diagnoses with a longitudinal approach over a 12 month interval. Participants will be healthy participants recruited through Prolific an on-line crowdsourcing service, and psychiatric patients and healthy participants recruited via UCLA Psychiatry Clinics and UCLA's STAND Program

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • All participants must be ages 18 to 65.
  • All must be able to understand and do the study tasks and communicate.
  • All must be able to understand the study and agree to take part.
  • Healthy participants must have no current mental health diagnosis, as checked by a study psychiatrist.
  • Patients must have depression, an anxiety disorder, or obsessive-compulsive disorder (unwanted thoughts and repeated actions).
  • Patients may also have bipolar disorder, but cannot be in an active manic phase (a period of unusually high energy or mood).
  • Patients may also have autism or ADHD (a condition that affects attention and activity levels).

Who can't join

  • All participants: Any past or current disease of the brain or nerves.
  • Patients: Any past or current psychotic disorder (a condition that affects a person's sense of what is real).
  • Patients: A current, active substance use disorder (a pattern of alcohol or drug use that causes problems).

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion criteria (healthy control participants): * Age range of 18 to 65. * Not currently having a psychiatric diagnosis determined after psychiatric evaluation by Drs. Tadayon-Nejad and Wei (both are board certified psychiatrists). * Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks. * Ability to give informed consent. Exclusion criteria (healthy control participants): • Prior history and or current diagnosis of neurological disease. Inclusion criteria (patients): * Age range of 18 to 65. * Psychiatric diagnosis of any type of depressive disorders, any type of anxiety disorders or obsessive-compulsive disorder. * Primary or comorbid bipolar disorders are allowed but only if not in the acute manic phase. * Comorbidity with autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) are allowed. * Ability to understand and perform experimental tasks, i.e. basic ability to communicate and comprehend tasks. * Ability to give informed consent. Exclusion criteria (patients): * Prior history and or current diagnosis of neurological disease. * History or current diagnosis of psychotic disorders. * Currently active substance use disorder.

Study sites (2)

CA