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Ketogenic Diets for Weight Loss Maintenance: Impact on Energy Expenditure and Appetite in Individuals With Obesity

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 65 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether a ketogenic diet, a very low-carb diet, helps people burn more energy and manage appetite while keeping weight off. It is for adults ages 18–65 with obesity who do little to moderate exercise.

The goal of this clinical trial is to investigate whether a Ketogenic Diet (KD) can increase Total Energy Expenditure (TEE), while benefiting appetite, during weight loss maintenance in reduced-obese individuals.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have a BMI of 30–45. BMI is a measure of weight compared with height.
  • Men and women ages 18–65 may join.
  • Do less than 2 hours of planned, moderate exercise each week.

Who can't join

  • Are pregnant or breastfeeding. Women who have not reached menopause must have periods every 26–30 days or use hormonal birth control.
  • Use tobacco daily, more than 1 pack per week.
  • Have gained or lost more than 5 pounds in the past 3 months.
  • Have problems with thinking or memory, or a history of an eating disorder.
  • Have had weight-loss surgery.
  • Have a condition such as type 2 diabetes, polycystic ovary syndrome (PCOS), an inflammatory disease, untreated thyroid disease, or fluid buildup linked to kidney disease, heart failure, or liver scarring.
  • Take medicine judged to affect study results, such as certain steroids, GLP-1 medicines, or hormone replacement therapy.
  • Have fasting blood sugar above 125 mg/dL or HbA1c above 6.4%. HbA1c measures average blood sugar over time.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * BMI 30-45 kg/m2 * Both men and women * Age between 18-65 years * Sedentary to moderately active (\<2 h/wk of moderate, structured, intentional, exercise) Exclusion Criteria: * Pregnancy or lactation * Daily use of tobacco (\>1 pk/wk) * Change in weight greater than 5 lb in the previous 3 months * Cognitive impairment * Previous bariatric surgery * History of eating disorder * Presence of any condition (e.g. DM2, PCOS, inflammatory disease, untreated thyroid disease, fluid overload states such as chronic kidney disease, congestive heart failure, or cirrhosis) * Use of any medication (e.g., glucocorticoid, GLP-1 analogues, hormone replacement therapy) deemed to interfere with study outcomes. * Pre-menopausal women will need to have a regular menstrual cycle (28+/-2 days) or be on hormonal contraceptives * Fasting glucose plasma concentration \>125 mg/dl and/or HbA1c \> 6.4%

Study sites (1)

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