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Impact of Depression on Thermoregulation

Thermoregulatory Responses to Heat Stress in Adults With Major Depressive Disorder With and Without Antidepressant Treatment

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 40 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether depression and certain depression medicines affect skin blood flow and sweating when the body is heated without exercise. It is for adults ages 18–40 with or without depression, including people taking SSRI or SNRI depression medicines.

The purpose of this study is to determine if, compared to non-depressed adults, differences exist in skin blood flow and sweating responses to passive heat stress in adults with clinically diagnosed depression, those with depression who are prescribed and taking SSRIs and those with depression who are prescribed and taking SNRIs.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Be age 18–40.
  • Have no depression, or have major depression diagnosed by a clinician. If you have depression, you must either take no antidepressants or have taken an SSRI or SNRI depression medicine for at least 2 weeks.
  • Have no signs of illness, such as chest pain or pressure, dizziness, joint pain, or signs of heart or blood vessel disease.
  • Meet the blood pressure rule at screening. The listing gives 140/90 mmHg but does not say whether readings must be below these numbers.
  • Have no diabetes and take no other medicines that could affect the study results.
  • Have an aerobic fitness score between the 20th and 80th percentiles for your age and sex. This score measures how well your body uses oxygen during exercise.
  • Be able to understand English.
  • Be able to understand the study and agree to take part.

Who can't join

  • Have a body mass index (BMI), a measure based on height and weight, over 35; be pregnant; or plan to become pregnant within 12 months.
  • Be in another exercise or weight-loss study, or plan surgery or a move out of the area within the next year.
  • Take medicines that affect heart, blood vessel, or body cooling responses, such as beta blockers, fever medicines, tricyclic antidepressants, or water pills. Also excluded: other drugs that affect mood or thinking within the past year, except SSRIs and SNRIs.
  • Use tobacco or illegal or recreational drugs, or have an allergy to latex or adhesive.
  • Have chest, muscle, bone, or joint pain during activity; be unable to safely complete a maximum-effort exercise test; or have an abnormal ECG, a test of the heart’s electrical activity.
  • Have a bleeding disorder, stomach ulcer, asthma, kidney or liver disorder, an allergy to NSAIDs such as ibuprofen, or take other blood thinners.
  • Have a history of Crohn’s disease, diverticulitis, or a similar disease of the digestive tract.
  • Have another mental health disorder, such as psychosis, schizophrenia, bipolar disorder, panic disorder, or obsessive-compulsive disorder; or have current suicidal thoughts rated as moderate or high risk.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Non-depressed adults aged 18-40 years; * OR adults aged 18-40 years with clinically diagnosed major depressive disorder according to DSM-V criteria not currently receiving antidepressant treatment; * OR adults aged 18-40 years with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a selective serotonin reuptake inhibitor; * OR aged 18-40 years adults with clinically diagnosed major depressive disorder with at least 2 weeks of treatment with a serotonin norepinephrine reuptake inhibitor; * All participants will be asymptomatic and no signs/symptoms of disease according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription (chest pain or pressure, dizziness, joint pain, and signs of cardiovascular disease); * Systolic blood pressure 140 mmHg and diastolic pressure 90 mmHg at screening; * Non-diabetic * Not taking any other medications that might affect the physiological variables of interest (beta blockers, tricyclic antidepressants, antipyretics, diuretics, etc.);; * Between the 20th and 80th percentiles for sex- and age-appropriate VO2max according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription; * English proficiency; * Capable of providing informed consent. Exclusion Criteria: * BMI \> 35 * Are pregnant or planning to become pregnant in the next 12 months; * Concurrently participate in another study involving physical activity or weight loss; * Plan to have surgery or relocate outside the area within the next year; * Medications that could alter cardiovascular or thermoregulatory responses to exercise (beta blockers, antipyretics, tricyclic antidepressants, diuretics, etc.); * Allergy to latex or adhesive; * Tobacco use; * Illegal/recreational drug use; * Exertional chest pain or musculoskeletal pain; * Contraindications to a maximal exercise test or an indication for early termination of the exercise test according to the American College of Sports Medicine 10th edition Guidelines for Exercise Testing and Prescription; * Abnormal resting or exercise electrocardiogram (ECG); * Any bleeding disorders, gastric ulcers, allergies to NSAIDS, asthma, kidney/liver disorders, and taking any other anticoagulants; * History of Crohn's disease, diverticulitis, or similar gastrointestinal disease; * Co-morbid psychiatric disorders (psychosis, schizophrenia, bipolar disorder, panic disorder, obsessive compulsive disorder, etc.); * Active suicidal ideation (moderate or high suicidality); * Use of psychoactive or psychopharmacological drugs other than SSRI and SNRIs within one year of participating.

Study sites (1)

PA