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Project neuroARTEMIS

Project ARTEMIS: A Mechanistic Clinical Trial of Neuroimmune Pathways.

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 59 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants who meet initial eligibility criteria will complete a baseline assessment that includes psychosocial and behavioral measures, biospecimen collection, and an MRI brain scan."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

Project neuroARTEMIS studies how long-term stress affects the brain, immune system, and mood. It tests whether a program that builds positive feelings can reduce stimulant use and depressed mood. It is for adults with HIV who take daily HIV medicine and use stimulants.

The purpose of this research is to understand how chronic stress affects the way our brain and immune systems function, and in turn how this affects the way people feel, think, and behave. By learning more about how these processes work, the hope is to be able to develop better treatments to help with problems like depression and substance use. This study is intended for individuals that are HIV positive, currently taking prescription antiretroviral medications, and use stimulants. Through this intervention, the aim is to determine if this positive affect intervention can lead to reductions in stimulant use and depressed mood.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 18–59 years old.
  • You reported using stimulants weekly in the past month, or scored 4 or higher on the ASSIST substance use screening test.
  • You have a confirmed HIV diagnosis.
  • You currently take daily HIV medicine by mouth, called antiretroviral therapy (ART).
  • You can speak and read English fluently.

Who can't join

  • You have an active brain infection, such as neurosyphilis or toxoplasmosis.
  • You currently have severe symptoms of bipolar I disorder or a psychotic disorder, which can affect your sense of reality.
  • You are prescribed medicine or treatment that changes how your immune system works.
  • You have a condition or other reason that makes an MRI scan unsafe.
  • If you take antidepressants, you have been on your treatment plan for at least 2 months. The study lists this as an exclusion.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * 18-59 years old * Weekly use of stimulants reported in the past month or a score of 4 or more on the Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) * Confirmed HIV diagnosis * Current receipt of daily oral antiretroviral therapy (ART) medication * English fluency/literacy Exclusion Criteria: * Acute brain infection (e.g., neurosyphilis, toxoplasmosis) * Acutely symptomatic bipolar I or psychotic disorder * Prescription for immunomodulatory medications or other immunotherapy * Any MRI contraindications * If applicable, on antidepressant medication regimen for at least 2 months

Study sites (1)

NC