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Effects of Body Composition on Vascular Health in Females With a Healthy Body Weight

Resting Indicators of Vascular Health and Cardiovascular Reactivity in Females With "Normal-Weight Obesity"

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 50 Years
Sex
Female only
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Visits mentioned: 2 visits, 1 visit
  • Procedures mentioned: Blood draws

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "We will have participants come to the lab for two different study visits."
  • "At one visit, participants will eat a meal high in fat, and at the other visit, participants will undergo a stress task."
  • "At the meal trial, an intravenous catheter will be inserted and baseline blood sample collected."
  • "Following completion of the meal, blood samples will also be collected 1, 2, 3, and 4 hours after the meal."
  • "At the stress trial, an intravenous catheter will be inserted and baseline blood sample collected."
  • "Then, blood samples will be collected at 10, 60, and 90 minutes after the stress task."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

Most of the time, body weight is evaluated by looking at the ratio of your weight to your height. This measurement is called body mass index or BMI. However, BMI does not account for what your body is actually made up of (e.g., body fat versus muscle), which may be more important for determining cardiovascular disease risk. The investigators aim to understand vascular health in females with a "healthy" BMI with differing amounts of body fat and muscle mass. We will have participants come to the lab for two different study visits. At one visit, participants will eat a meal high in fat, and at the other visit, participants will undergo a stress task.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * You are 18-50 years old * Your biological sex is female * BMI is in "normal" category (18.5-24.9 kg/m2) - this BMI requirement is due to our research aims * You are not pregnant or expecting to become pregnant * You are not postmenopausal * You have not been diagnosed with a cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes) * You have not been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease). * You do not regularly take anti-inflammatory drugs (more than 2x week) or are able to temporarily suspend use of anti-inflammatory drugs. * You do not use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin) tobacco products, or any illicit drugs * You do not have a pacemaker. * You do not have dietary restrictions prohibiting you from eating the provided meal (e.g., vegan/vegetarian diets, gluten-free diet, relevant food allergies). * You are able to stay in the supine position in the dark for at least 10 minutes Exclusion Criteria: * You are not 18-50 years old * Your biological sex is not female * Your BMI is not in the "normal" category (18.5-24.9 kg/m2) - this BMI requirement is due to our research aims * You are pregnant or expecting to become pregnant (females only) * You are postmenopausal * You have been diagnosed with a cardiometabolic condition (e.g., cardiovascular disease, type 2 diabetes) * You have been diagnosed with a chronic inflammatory condition (e.g., rheumatoid arthritis, inflammatory bowel disease). * You regularly take anti-inflammatory drugs (more than 2x week) or are unable to temporarily suspend use of anti-inflammatory drugs. * You use lipid-lowering drugs (e.g., statins), glucose-lowering drugs (e.g., metformin) tobacco products, or any illicit drugs * You have a pacemaker. * You do have dietary restrictions prohibiting you from eating the provided meal (e.g., vegan/vegetarian diets, gluten-free diet, relevant food allergies). * You are unable to stay in the supine position in the dark for at least 10 minutes

Study sites (1)

IN