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Interactive Roles of Cardiorespiratory Fitness and Adiposity on Glucose and Vascular Control After Physical Inactivity

Interactive Roles of Cardiorespiratory Fitness and Adiposity on Recovery of Impaired Glucose and Vascular Control After Physical Inactivity

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 40 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how fitness and body fat affect blood sugar and blood vessel health after a week of less activity. It also tests how blood sugar recovers when normal activity starts again. It is for active adults ages 18 to 40 with different fitness and body fat levels.

The far-reaching negative health effects of the reduced physical activity (RPA) epidemic are often overlooked by the general population and health professionals. Short-term RPA induces cardiometabolic dysfunction, including impaired glucose control and vascular function, that may precede disease development. The impact of existing health status on RPA-induced cardiometabolic dysfunction and recovery of impaired glucose control following RPA is unexplored. Thus, the investigators' objectives are 1) to investigate the effect of existing health status (cardiorespiratory fitness and adiposity) on the recovery of impaired glucose control following a period of RPA and 2) to determine the role of vascular function as a mechanism of impaired glucose control. The investigators' final objective is to 3) expose undergraduate students to meritorious biomedical clinical research methods. The investigators have piloted the clinical research methods and analysis with undergraduate researcher associates and are well-prepared to complete this proposal. Preliminary data show that low cardiorespiratory fitness and/or high adiposity impair the recovery of glucose control following short-term RPA. Thus, the investigators aim to examine the interactive role of health status (cardiorespiratory fitness and adiposity) on the ability to recover impaired glucose control following short-term RPA. The investigators also seek to examine changes in vascular function as a mechanism of recovery of impaired glucose control following a return to normal PA. The investigators will recruit men and women with divergent health status (cardiorespiratory fitness and adiposity) to examine glucose control and vascular function during 7-d of normal PA, 7-d of RPA, and 7-d of resumption of normal RA. Continuous glucose monitoring and oral glucose tolerance tests will be performed to assess glucose control. Increases in vascular shear stress induced by passive leg movement and central arterial stiffness will be measured to assess vascular function.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Be 18 to 40 years old. Men and women may join.
  • Be able to safely ride an electric scooter for at least 10 minutes.
  • Take more than 7,000 steps a day and walk more than 1 mile outdoors each day.
  • Have had a stable body weight for at least 1 year.
  • Meet the study's fitness and deep belly fat requirements.

Who can't join

  • An injury that keeps you from exercising regularly at screening.
  • A pacemaker or implanted defibrillator, which helps control your heartbeat.
  • Current cancer.
  • Alcohol or drug abuse.
  • Use of a device to help you walk.
  • Major signs or symptoms of heart, blood vessel, lung, or metabolism disease, based on a health questionnaire. Metabolism is how your body uses food for energy.
  • Taking more than 500 mg of vitamins each day during the study.
  • Using acetaminophen or aspirin during the study.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Males and females 18 to 40 years of age. * Ability to safely ride an electric scooter (e-scooter) for at least 10 minutes. * Active (\>7000 steps per day, walking \> 1 mile a day outside) * Stable body weight for at least 1 year * aerobic fitness level, CRF is \< 9 and \>14 METS * Visceral adipose tissue \<130 cm2 or ≥130 cm2 for men and \<100 cm2 or ≥100 cm for women Exclusion Criteria: * Any injury preventing them from exercising regularly at the time of the screening. * Implantable defibrillator or pacemaker * Active cancer * Alcohol or drug abuse * Use of an assistive walking device * Presence of significant signs/symptoms of cardiovascular, metabolic, or pulmonary disease (determined from the American College of Sports Medicine (ACSM) Health History Questionnaire) * Daily vitamin consumption of \> 500mg per day during the study * Acetaminophen or aspirin use during the study

Study sites (1)

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