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Brain and Behavior Influences on Obesity Development From Infancy Through Childhood

Early Brain Development and Child Nutrition and Obesity

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
7 Years to 12 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Further, although functional magnetic resonance imaging (MRI) studies have identified altered patterns of activation in brain appetite circuits in association with pediatric obesity and early risk factors for obesity, the predictors of altered functioning of brain appetite circuits in middle childhood are unknown."
  • "Finally, although preclinical research and MRI studies of children under 9 years of age support that hypothalamic gliosis, a cellular inflammatory response, plays a role in obesity pathogenesis, it is unclear whether it occurs or impacts appetite in earlier life."
  • "For the proposed study, RESONATE, the investigators will address the above research gaps by extending the RESONANCE study to administer meal tests, behavioral and functional magnetic resonance imaging (fMRI) tasks assessing food and non-food reward and cognitive control, and weight/ adiposity measures in middle childhood, and examining hypothalamic gliosis, in a sub-sample of RESONANCE children."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

The RESONATE study looks at why some children develop obesity, or too much body fat. It studies eating habits, genes, surroundings, and how the brain is built and works. It is for children already in the RESONANCE study who will be ages 7–12 during this project and have no food allergies.

The investigators project, RESONATE, aims to investigate why some children develop obesity. To do this it uses data on eating and eating-related behaviors, genetic and environmental factors, and brain structure and function. This data is collected in a sub-sample of RESONANCE, a large study of families of children from infancy through childhood. The results will lay foundations for the development of early interventions to prevent or treat obesity.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Already part of the RESONANCE study.
  • Will be ages 7–12 during the project.
  • Have no food allergies.

Who can't join

  • Exposure to alcohol, cigarettes, or illegal drugs before birth.
  • Unusual findings on an ultrasound scan in the first 3 months of pregnancy.
  • Problems during pregnancy, such as pre-eclampsia, a condition involving high blood pressure.
  • Problems during birth, including an APGAR score below 8 (a newborn health check) or a stay in newborn intensive care.
  • A history of brain or nerve disorders, such as epilepsy (seizures); mental health disorders, such as anxiety or depression needing medicine; or developmental disorders, such as autism or dyslexia (trouble reading).
  • Cannot safely have an MRI scan, such as because of metal in the body, or have a fear of tight spaces.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Participants from the RESONANCE cohort are eligible if the participant will reach 7-12 years of age during the proposed project period and have no food allergies. Exclusion Criteria: * Exclusion criteria for RESONANCE include: 1. In utero exposure to alcohol, cigarette, or illicit substances; 2. First trimester fetal US abnormalities; 3. Complicated pregnancy (e.g., pre-eclampsia); 4. Complicated delivery, including APGAR scores less than 8 and/or neonatal intensive care unit (NICU) admission; 5. History of neurological (e.g., epilepsy), psychiatric (e.g., anxiety or depression requiring treatment with medication) or developmental disorder (e.g., autism spectrum disorder (ASD), dyslexia); 6. Contraindications for MRI including metal in the body, claustrophobia.

Study sites (4)

MD

RI

WA