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Circadian Rhythms in Human Adipose

Circadian Regulation of Human Adipose Tissue Metabolism

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 55 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Blood draws, Biopsies

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "After baseline blood samples, the CONT feeding group will start liquid feedings (Ensure Plus®) at 1800 and continue for the next \~37 hrs."
  • "This will provide 12 h of continuous feeding before the first abdominal AT biopsies; this duration of continuous feeding abolishes the wide fluctuations in plasma insulin that occurs with normal meals and will avoid the progressive lipolytic response that would occur if fasting were used as the experimental design."
  • "To ensure a full 24 hours of data, all participants will have biopsies at: 0600, 1800, and 0600 the next day, half of participants will have a biopsy at 1200 and the other half at 2400."
  • "This hybrid (linked-cross sectional) will allow us to sample in series from multiple people and then create sample group means to account for disparate biopsy numbers."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at daily body-clock patterns in fat under the skin, with and without continuous feeding. It includes people with and without obesity to see how obesity changes these patterns.

The goal of this study is to understand the underlying circadian rhythms in subcutaneous adipose tissue of humans with our without continuous feeding and how these are altered in people who have obesity.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have a BMI of 20–25 or 30–37. BMI is a measure of weight compared with height.
  • If you have obesity, have a waist-to-hip ratio of at least 0.95 for males or 0.90 for females. This compares your waist size with your hip size.
  • Do little or no regular physical activity.
  • If female, are not pregnant or breastfeeding.
  • Can give written consent to join and follow study instructions.

Who can't join

  • Have used medicines that affect how fat cells work or how the body processes fat.
  • Smoke.
  • Have insomnia, or trouble falling or staying asleep.
  • Have sleep apnea, which causes breathing to stop and start during sleep.
  • Use sleep medicines.
  • Work night shifts or do shift work.
  • Naturally sleep and wake at unusually early or late times.
  • Are allergic to lidocaine, a numbing medicine.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * BMI 20-25 kg/m2 or 30-37 kg/m2 * For participants with obesity a waist-to-hip ratio of ≥0.95 in males and ≥0.90 in females. * sedentary * females: non pregnant or breastfeeding * ability to provide written informed consent and follow study instructions Exclusion Criteria: * History of mediations that impact adipocyte/lipid metabolism * smoking * insomnia * sleep apnea * sleep medication use * employment in night or shift work * extreme chronotypes * Allergy to lidocaine

Study sites (1)

MN