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Test of Target Engagement of Ambiguity Aversion

Computational Modeling of Ambiguity Aversion in Internalizing Disorders: Neural and Behavioral Markers, and a Test of Target Engagement

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
25 Years to 60 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Questionnaires

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will also be asked to complete questionnaires before completing the task and SSI."
  • "The questionnaires will be about the participant's emotions and symptoms of depression and anxiety, personality, and avoidance/tolerance of uncertainty."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether a single session can change how much people avoid choices with unknown risks. It looks at both their choices and their brain responses. It is for adults ages 25 to 60 who meet a score requirement for discomfort with uncertainty.

The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Are ages 25 to 60.
  • Are right-handed.
  • Can read and write English.
  • Can understand the study and agree to take part.
  • Have a score for discomfort with uncertainty at or above the 31st percentile.

Who can't join

  • Have ever had psychosis (trouble knowing what is real), mania, or hypomania (periods of unusually high mood or energy).
  • Have a history of autism spectrum disorder.
  • Have an IQ score below 80 on the Wechsler Test of Adult Reading.
  • Have had a head injury that made you pass out for more than 2 minutes.
  • Have a brain or nerve condition, such as epilepsy, Parkinson’s disease, cerebral palsy, or a past stroke.
  • Are currently pregnant.
  • Have an electrical device placed inside your body, such as a pacemaker, spinal or nerve stimulator, or Inspire sleep apnea device.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Ages 25 to 60 2. Right-handed 3. Ability to read and write English 4. Capacity to provide informed consent 5. Intolerance of uncertainty score ≥ -0.5 standard deviation below the mean (31st percentile) Exclusion Criteria: 1. Personal history of psychosis, mania, or hypomania 2. Personal history of autism spectrum disorder 3. IQ \< 80 as determined by the Wechsler Test of Adult Reading 4. Head injury with greater than 120 seconds loss of consciousness 5. Neurological condition (e.g., epilepsy, Parkinson's, cerebral palsy, history of stroke) 6. Currently pregnant 7. Use of any implanted electrical device (e.g., pacemaker, spinal stimulator, vagal nerve stimulator, Inspire sleep apnea device, etc.).

Study sites (1)

IL