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Impact of Lean Pork on Endothelial Function in Perimenopause

Effects of Lean Pork Intake on Endothelial Function and Vasomotor Symptoms in Perimenopausal Women

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
40 Years to 55 Years
Sex
Female only
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 4 weeks

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will consume both of the following diets, each for 4 weeks, with a washout period between 2 and 6 weeks in between the diets when participants will consume their usual diet."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

The goal of this study is to examine the impact of a diet high in fresh lean pork, compared to a plant-based diet, on cardiovascular function and vasomotor symptoms in perimenopausal women with overweight and obesity. The main questions it aims to answer are: 1. How does a diet high in pork, compared to a plant-based diet, affects blood lipids, endothelial function, and blood pressure? 2. How does a diet high in pork, compared to a plant-based diet, affects blood nitrate, cardiometabolic biomarkers, inflammatory biomarkers, and vasomotor symptoms? Researchers will compare the diet high in pork to a plant-based diet to see if pork helps improve cardiovascular and mesopause symptoms. Participants will: * Consume both of the diets, each for 4 weeks, with a washout period between 2 and 6 weeks in between the diets trials * Visit the clinic 5 times with weekly meal pick ups during the diet trials * Undergo testing procedures including: weight and body composition, blood pressure and pulse, endothelial function using ultrasound of upper arm, microvascular blood flow, blood draws, physical activity measurements, and questionnaires.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Are female * Are between 40 and 55 years of age * Have a BMI (a number calculated from participant height and weight) between 28 and45 kg/m2 * Are experiencing irregular menstrual cycles but have not gone longer than 12 consecutive months without a period * Are experiencing severe vasomotor (menopause) symptoms * Are doing less than 3 hours per week of structured exercise * Have systolic blood pressure between 120 and 140 mmHg and/or diastolic blood pressure between 80 and 90 mmHg * Have "sugary" hemoglobin called hemoglobin A1c less than or equal to 6.5% * Are willing and able to refrain from using oral mouth wash for the duration of the study because the alcohol in mouth wash inhibits nitrate synthesis * Are willing and able to comply with both the study diets * Are willing to collect blood for future research * Can read, speak, and understand English Exclusion Criteria: * Hysterectomy (partial or full) or oophorectomy * Using hormone replacement therapy use and/or hormonal contraception use 6 months prior to study start * Has systolic blood pressure ≥140 mmHg and/or diastolic blood pressure ≥ 90 mmHg) * Triglycerides ≥350 mg/dL, low-density lipoprotein cholesterol (LDL-C) ≥190 mg/dL, and/or taking a lipid-lowering medication -Diagnosed cardiovascular disease, diabetes (type 1 or 2), or endocrine- related disease (e.g. thyroid, PCOS), unstable gastrointestinal disease, kidney, liver, and/or pancreatic disease * Diagnosed cancer (except skin cancer) in the last 5 years * Taking \>1 blood pressure medication and/or taking 1 blood pressure medication for \<3 months * Taking phosphodiesterase-5 inhibitors, anti-coagulants, corticosteroids, metformin, or insulin. * Weight change ≥6.6 pounds in the past 3 months, actively trying to lose weight, or unwilling to remain weight stable throughout the study * Current smoking or vaping, Binge and/or heavy drinker * Food allergies or other reasons preventing consumption of study foods with both study diets

Study sites (1)

LA