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Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity

Upper Body Subcutaneous Adipose Tissue Outflow Response to a Meal

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 55 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at tiny particles called exosomes released by fat under the skin of the upper body after a meal. It compares people at a normal weight with people who have obesity, using blood samples from different sites.

The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific cannulation of the superior epigastric vein. We will characterize the exosome signatures in response to a meal and compare to the exosome signature of arterialized venous plasma samples.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Women must not have gone through menopause, when monthly periods stop.

Who can't join

  • Taking medicines that affect blood flow, such as statins or beta-blockers.
  • Taking medicines or supplements that affect how the body handles fats or fat tissue, such as TZDs or high-dose fish oil.
  • Having diabetes or a history of heart or blood vessel disease.
  • Being allergic to lidocaine, a numbing medicine.
  • Having gone through menopause.
  • Being pregnant.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: • All women must be premenopausal Exclusion Criteria: * Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements) * Diabetes, history of cardiovascular disease * Allergy to lidocaine * Post-menopausal women * Pregnant

Study sites (1)

MN