RecruitingPhase 1 / Phase 2

A Clinical Study to Test if an Investigational Treatment Called BNT314 When Used in Combination With Another Investigational Treatment Pumitamig (BNT327) and Chemotherapy, is Beneficial and Safe for Patients With Advanced Colorectal Cancer

A Phase I/II, Randomized, Multi-site Trial to Investigate the Efficacy and Safety of BNT314 in Combination With Pumitamig and Chemotherapy in Participants With Metastatic Colorectal Cancer

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether BNT314, given with pumitamig (BNT327) and chemotherapy, is safe and helps treat colon or rectal cancer that has spread. BNT314 and pumitamig are new treatments meant to help the body's defenses fight cancer.

This randomized, multi-site, three-part study will test a new treatment called BNT314, which is designed to help the body's own defense to fight cancer in combination with another new treatment (pumitamig, which is a cancer immunotherapy drug also known as BNT327 and PM8002) and chemotherapy in participants with metastatic colorectal cancer (mCRC).

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have colon or rectal adenocarcinoma, a cancer that starts in gland cells, confirmed by a tissue test. The cancer must have spread and cannot be removed by surgery.
  • Have cancer with certain DNA repair test results called non-MSI-H/pMMR.
  • Have cancer that can be measured on scans.
  • Provide a tumor tissue sample before treatment. A new sample is preferred; an older sample may be allowed.
  • Be fully active or able to do light work, and be expected to live at least 12 weeks.
  • Have organs and bone marrow working well enough on tests done within 7 days before treatment.
  • Wait the required amount of time after earlier treatment before joining.
  • Meet your study group's rules for past treatment. Some groups require cancer to have worsened after one or at least two treatments; another requires no past whole-body treatment for cancer that has spread. Other study rules apply.

Who can't join

  • Have cancer with DNA repair test results called MSI-H/dMMR, or have received certain immune-based cancer treatments listed in the study rules.
  • Could receive surgery, focused radiation, or another local treatment that may give complete or nearly complete, lasting cancer control.
  • Have serious or uncontrolled heart disease, heart pumping strength below 50%, or uncontrolled fluid around the lungs, heart, or belly needing recent drainage treatment.
  • Have active cancer in the brain or spinal cord area, or an immediate risk of pressure on the spinal cord. Some people with stable brain cancer spread may qualify.
  • Still have more than mild side effects from past cancer treatment, with some exceptions. In Parts B and C, unusual past treatment side effects or low DPD, an enzyme that breaks down certain drugs, may also rule you out.
  • Have another recent cancer or another cancer that is growing or needs treatment, with some exceptions; a bowel blockage needing a hospital stay in the past 3 months; or too much protein in urine.
  • Have certain diseases in which the body's defenses attack healthy tissue, or have a weakened immune system, including after an organ or donor stem cell transplant. Some exceptions apply.
  • Have serious wounds or broken bones that have not healed, certain recent belly or gut problems, or major blood-clotting or bleeding risks. Other study rules apply.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Key Inclusion Criteria: * Have unresectable histologically confirmed adenocarcinoma of the colon or rectum. * Have confirmed non-microsatellite instability-high (non-MSI-H)/pMMR mCRC per Food and Drug Administration (FDA)/European Commission (EC) approved test or based on local testing. * Have measurable disease defined by RECIST v1.1. * Must provide a tumor tissue sample (formalin-fixed, paraffin-embedded or tissue slides) collected before C1D1 for enrollment. A newly obtained tumor sample is preferred. If it is not feasible to obtain a recent tumor sample, participants can provide archival tumor tissue (less than 2 years prior treatment). * Have Eastern Cooperative Oncology Group Performance Status of 0 or 1. * Have a life expectancy of ≥12 weeks. * Have an adequate organ and bone marrow function within ≤7 days of Day 1 as defined in the protocol. * Have had an adequate previous treatment washout period before randomization/enrollment as defined in the protocol. Inclusion criteria applicable to only protocol-specific cohorts: * Have histologically confirmed metastatic colorectal cancer and radiographically documented disease progression after ≥2 prior lines of systemic therapy for metastatic disease as defined in the protocol. * Have progressed following first-line chemotherapy as specified in the protocol. * Have not received prior systemic therapy for MSS/pMMR mCRC. Participants who received chemotherapy, radiotherapy, or chemoradiotherapy with curative intent for non-metastatic disease in the neoadjuvant or adjuvant setting are eligible for the study if therapy was completed at least 6 months prior to initiation of study treatment. Other cohort-specific inclusion criteria apply. Key Exclusion Criteria: * Confirmed MSI-H/deficient mismatch repair mCRC (per FDA/CE approved test or based on local testing). * Prior treatment with epithelial cell-adhesion molecule or 4-1BB targeted or immunotherapy. * Prior treatment with immune checkpoint inhibitors or programmed death-ligand 1 (PD\[L\]-1)/vascular endothelial growth factor bispecific antibody. * Is a candidate to locoregional treatment (including surgical resection, stereotactic radiation therapy or tumor ablation) with potential to induce complete or near complete response and prolonged tumor control (sometimes described as "radical" intent), per investigator's assessment. * Have uncontrolled or significant cardiovascular disease as specified in the protocol. * Have left ventricular ejection fraction \<50% by echocardiogram or multigated acquisition within 28 days before randomization/enrollment. * Have clinically uncontrolled pleural effusion, ascites or pericardial effusion requiring drainage, peritoneal shunt, or cell-free concentrated ascites reinfusion therapy within 2 weeks prior to randomization/enrollment. * Have clinically active central nervous system metastases, defined as untreated and symptomatic, or requiring therapy with corticosteroids or anticonvulsants to control associated symptoms. Participants with treated brain metastases that are no longer symptomatic and who require no treatment with corticosteroids or anticonvulsants may be included in the study if they have recovered from the acute toxic effect of radiotherapy. Participants with untreated, asymptomatic brain metastases for whom local therapy is not indicated per SoC may be eligible if neurologically stable and (if deemed necessary by the investigator). Except for brain metastases history, any participants at imminent risk for spinal cord compression or leptomeningeal disease are not eligible. * Have unresolved toxicities from previous anticancer therapy, defined as toxicities (other than alopecia) not yet resolved to Grade ≤1 or baseline toxicities that have resolved with sequelae (e.g., tracheostomy, chronic use of feeding tube, replacement hormones) are allowed, if not associated with increased risk of complications per investigator's assessment. * Participants in Part B or C who fulfill one of the conditions: * Prior treatment with anticancer therapies (as defined in the protocol) with unusual toxicity, or * Known dihydropyrimidine dehydrogenase (DPD) deficiency, testing performed according to the local guidelines. If not tested, lack of DPD activity must be tested for the participants who have not received anticancer therapies (as defined in the protocol) in the prior lines of treatment; testing should be performed according to the local guidelines. * Have a history of another primary malignancy within 2 years, except adequately resected non-melanoma skin cancer, curatively treated in-situ disease, or other solid tumors curatively treated (adjuvant hormone therapy for malignancies at low risk of relapse is allowed) or have a known additional malignancy that is progressing or requires treatment. * Have a history of small bowel obstruction requiring hospitalization within the past 3 months prior to the first dose of IMP. * Have 24-h urine protein excretion ≥1 g. If qualitative urine protein is ≤1+, a 24-h urine protein quantitative test is not required. * Have active autoimmune disease or a history of autoimmune disease (myasthenia gravis, myositis, autoimmune hepatitis, systemic lupus erythematosus, rheumatoid arthritis, psoriatic arthritis, inflammatory bowel disease, vasculitis, antiphospholipid antibody syndrome, Wegener granulomatosis, Sjögren's syndrome, Guillain-Barré syndrome, or multiple sclerosis) with a risk of exacerbation following PD-L1 inhibition or have an immune deficiency (allogeneic hematopoietic stem cell transplantation or organ transplantation). Participants with protocol-specified conditions may be eligible. * Have serious non-healing wounds, ulcers, or bone fractures. This includes history of abdominal fistula, gastrointestinal perforation, or intra abdominal abscess or esophageal and gastric varices, acute gastrointestinal bleeding for which an interval of 6 months must pass before enrollment into this study. In addition, the participant must have undergone correction (or spontaneous healing) of the perforation/fistula and/or the underlying process causing the fistula/perforation. * Have evidence of major coagulation disorders or other significant risks of hemorrhage as specified in the protocol. NOTE: Other protocol defined Inclusion/Exclusion criteria apply.

Study sites (4)

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MI

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  • Cleveland Clinic Taussig Cancer Institute Case Comprehensive Cancer Center · Cleveland, OH 44195More trials in Cleveland

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