Comparing the Efficacy of Heated Yoga and Sauna as a Treatment for Depression
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years to 65 Years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study tests whether heated yoga, sauna sessions, and a mindfulness app can reduce depression symptoms. It is for adults ages 18–65 with at least moderate depression symptoms.
This project explores whether heated yoga, sauna, and a mindfulness app reduce depressive symptoms
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Be 18–65 years old.
- Understand English and be able to agree to join the study.
- Score above 10 on the PHQ-9, a survey about depression symptoms.
- Fill out the required waiver forms before joining.
- Use an accepted form of birth control if you could become pregnant.
- Keep mental health medicines and talk therapy unchanged during the study, if you use them.
- Have a device that can use the mindfulness app and a healthcare provider you can contact for care.
- Be able to travel to Breathe in Harvard Square and a Restore site in Hingham, Somerville, Dedham, Newton, or Lynnfield.
Who can't join
- Are pregnant, planning pregnancy, or breastfeeding.
- Have current suicidal thoughts that meet the study’s screening rules; an active eating or substance use disorder within the past year; OCD or PTSD as your main condition; or a history of bipolar disorder or psychosis, which can affect your sense of reality.
- Have depression survey scores that drop by 25% or more between screening and the first study visit, or have been hospitalized for mental health care in the past year.
- Are under the influence of drugs or alcohol, are in withdrawal, or have a positive urine test for illegal drugs or medicines the study does not allow. Possible false-positive results will be reviewed.
- Had a broken bone or joint surgery in the past 6 months; have trouble walking; have a serious, unstable illness without your doctor’s approval; or have a brain or nerve disorder that could make joining unsafe.
- Take medicines that raise dehydration risk or are otherwise not allowed; have trouble sweating; have hemophilia, a bleeding disorder; or have a pacemaker.
- Started a mental health medicine less than 8 weeks before screening, changed its dose less than 4 weeks before screening, or started talk therapy in the past 3 months. Current ketamine, electroconvulsive therapy, or transcranial magnetic stimulation treatments are also not allowed.
- Had more than 6 heated yoga classes, sauna sessions, or mindfulness app uses in the past 3 months; cannot follow study steps or travel to study sites; or the study leader believes you cannot safely finish or could affect the study’s reliability.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Subject Characteristics Inclusion Criteria: 1. adults (18-65 years old) 2. Ability to provide informed consent 3. English language proficiency 4. PHQ-9 score \> 10, indicating at least moderate depressive symptoms 21 5. Must have filled out the waiver for the community-based partners prior to enrolling in the study\* 6. Individuals of childbearing potential must use an acceptable form of birth control 7. (if applicable) willingness to keep psychiatric medications and psychotherapy stable throughout the course of the study 8. Must be able to access mindfulness app on a device (i.e., smartphone, iPad, etc.) 9. Can travel to Breathe in Harvard Square and at least one Restore location (i.e., Hingham, Somerville, Dedham, Newton, Lynnfield) Exclusion Criteria: 1. Pregnant or planning to become pregnant 2. Breast feeding 3. Active suicidal thinking (i.e., PHQ-9 item 9 ≥1 and a positive response to C-SSRS screener items 3, 4, 5, or 6) 4. Active eating disorders or substance use disorders within the past 12 months, as per the MINI 5. Primary OCD or PTSD, as per the MINI 6. History of bipolar disorder, psychotic disorders, as per the MINI 7. ≥25% drop in PHQ-9 score from screen to baseline 8. Under the influence or withdrawal of drugs or alcohol 9. Positive urine toxicology screen due to illicit drug use or other exclusionary medications. (Potential false positives will be addressed on a case-by-case basis at the discretion of the PI or designee) 10. have had a bone fracture or joint surgery in the past 6 months 11. not able to walk freely or without difficulty 12. any serious, unstable medical condition as determined by the revised Physical Activity Readiness Questionnaire (PAR-Q+) and do not have approval from their treating physician (we will check in with treating physician in the event that participants endorse any item on the PAR-Q+) 13. participants must have a healthcare provider who they could contact if they needed medical care, such as a primary care doctor, a counselor, a psychiatrist, a nurse practitioner, or a clinic that you go to. 14. Significant exposure to heated yoga classes in the past 3 months (i.e., more than 6 classes) 15. Significant exposure to sauna sessions in the past 3 months (i.e., more than 6 sessions) 16. Significant exposure to mindfulness app in the past 3 months (i.e., more than 6 uses of the app) 17. are on medications that make dehydration more likely (e.g., lithium, antipsychotics, insulin-dependent) diuretics, barbiturates, b-blockers, anticholinergics, current ETOH acute intoxication, reduced ability to sweat, hemophilia, pacemaker (magnets used to assemble saunas can interrupt the pacer) 18. antidepressant or psychiatric medications that are initiated less than 8 weeks or a dose change less than 4 weeks prior to screening visit 19. psychotherapy that has been initiated within the past 3 months 20. psychiatric hospitalization within the past year 21. diagnosed with any neurological disorders that would impact participation or make participation unsafe 22. are currently in active ketamine, Electroconvulsive therapy, or Transcranial Magnetic Stimulation treatments 23. are unable to follow the study procedures (e.g., not able to travel to the heated yoga or sauna studios) 24. A subject who in the opinion of the Principal Investigator would not be able to safely complete the study or would jeopardize study integrity
Study sites (1)
MA
- Massachusetts General Hospital · Boston, MA 02114Maren B Nyer, PhD · Study contact · 617-726-8895 · mnyer@mgh.harvard.eduDavid Mischoulon, MD, PhD · Study contact · 617-726-8895 · dmischoulon@mgh.harvard.eduMore trials in Boston