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Enhancing Slow Wave Sleep in Depression

Investigating Slow Wave Sleep Enhancement to Improve Cognitive Function in Adults With Depression

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
40 Years to 80 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 2 weeks
  • Procedures mentioned: Questionnaires

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "In addition, participants will complete several cognitive assessments and mood and sleep questionnaires throughout the study."
  • "Participants will then receive TES nightly for two weeks."
  • "Finally, participants will complete several cognitive assessments and sleep and mood questionnaires throughout the duration of the study."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

The goal of this pilot study is to determine if non-invasive brain stimulation during sleep can increase deep sleep in adults with depression. It will also determine if increased deep sleep improves cognitive performance and mood ratings. Participants will be asked to wear a non-invasive device that records their brain activity and delivers transcranial electrical stimulation during sleep. Participants will also wear an actigraphy watch that measures activity levels throughout the study. In addition, participants will complete several cognitive assessments and mood and sleep questionnaires throughout the study.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Ability to complete overnight sleep study including placement of EEG leads * Ability to read and understand English. * Moderate depression * Self-reported cognitive complaints Exclusion Criteria: * Previous adverse reaction to transcranial electrical stimulation * Presence of implanted devices (e.g. intracranial device, cochlear implant) * Presence of metal in head (e.g. surgical clip) * Sensitivity or allergy to silver * Presence of significant neurologic disease (e.g. Parkinson's disease, epilepsy/seizure disorder, severe migraine disorder) * History of significant head trauma * History of stroke or other ischemic event * Diagnosed with schizophrenia, bipolar disorder, substance use disorder, or presence of current suicidal ideation * Currently taking medications that could alter EEG or cognitive function * Presence of severe insomnia * Presence of severe, untreated sleep apnea * Currently pregnant * Planned travel outside time zone during the study

Study sites (1)

NC