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Improving Outcomes in Adolescent Inpatient Depression With Deep Transcranial Magnetic Stimulation

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
14 Years to 18 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 12 months

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants (n=60) will be randomized to receive either active or sham TMS during hospitalization, with follow-up assessments continuing for 12 months post-discharge."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests deep transcranial magnetic stimulation (dTMS), which uses magnetic pulses to stimulate the brain, as an added treatment for depression. It is for teens ages 14–18 who are in the hospital with major depression. Researchers will check whether the treatment is practical, safe, and may help.

Evaluate the feasibility, safety, and preliminary efficacy of deep Transcranial Magnetic Stimulation (dTMS) as an adjunctive treatment for adolescents hospitalized with major depressive disorder (MDD).

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Are 14–18 years old.
  • Speak English fluently and can freely agree to join. Can explain the study's main parts, risks, and benefits in their own words.
  • Have major depressive disorder, as diagnosed by a psychologist using a standard checklist and interview.
  • Have moderate to severe depression, with a score above 20 on the Hamilton Depression Rating Scale.
  • May keep using their current treatments.

Who can't join

  • Have taken part in a trial of an experimental drug in the past 3 months.
  • Have a condition or device that makes magnetic brain stimulation unsafe, such as a history of epilepsy (a seizure disorder), metal objects inside the body, or an implanted medical device.
  • Currently have psychosis, such as confused thinking, false beliefs, strong unfounded fears, or seeing or hearing things that are not there.
  • Currently have a suicide plan, intend to act on it, and are under constant one-on-one observation.
  • Are female, able to become pregnant, and have a positive urine pregnancy test.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Fluent in English and able to volunteer in the informed consent process and provide spontaneous narrative description of key elements, risks, and benefits of the study. 2. Aged 14 years to 18 years, inclusive. 3. Diagnosis of MDD based on psychologist diagnosis and DSM-5-checklist based interview. 4. Symptoms of moderate to severe depression according to Hamilton Depression Rating Scale Score \> 20. 5. Participants are not required to discontinue current interventions Exclusion Criteria: 1. Participation in an investigational drug trial within the past three months. 2. Contraindications to Transcranial Magnetic Stimulation including, but not limited to, a history of epilepsy, the presence of metallic foreign bodies, or implanted medical devices (e.g. ventriculoperitoneal shunt, pacemaker, medical pump). 3. Actively psychotic (i.e. disorganized, delusional, paranoid, or having hallucinations) 4. Actively suicidal (have a suicidal plan and intent and is on 1:1 close observation) 5. For female subjects of childbearing potential, a positive urine pregnancy test.

Study sites (1)

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