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Timing of Opioid Administration and Postoperative Respiratory Depression.

The Relationship Between Timing of Opioid Administration and Postoperative Respiratory Depression.

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 85 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how the timing and dose of opioid pain medicine affect breathing after surgery. It is for adults ages 18 to 85 who will have general anesthesia, which puts them to sleep, and are expected to need opioid pain medicine afterward. The study checks breathing in the recovery room while patients breathe on their own without a breathing tube.

The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general anesthesia and have received perioperative opioids. The primary aim is to determine the temporal effect of opioid administration on respiratory depression as assessed by minute ventilation with a reduction of at least 20% in the percent of predicted minute ventilation. A secondary aim is to determine a dose response of opioid administration and its effect on minute ventilation. The investigators aim to determine the influence of opioid administration on minute ventilation on spontaneously breathing patients during post-anesthesia care unit (PACU) stay.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Give written consent to join the study.
  • Be 18 to 85 years old.
  • Plan to have general anesthesia lasting at least 2 hours.
  • Be expected to need opioid pain medicine after surgery.

Who can't join

  • Have a procedure that is not surgery, such as an imaging scan.
  • Will not go to the recovery room after surgery.
  • Use a pain medicine pump that lets you give yourself doses.
  • Are pregnant or breastfeeding.
  • Have lung disease that affects the two lungs differently.
  • Have an ASA V rating, meaning you are very ill and are not expected to survive without surgery.
  • Need emergency surgery.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Written informed consent * Adults ≥18 years of age and ≤85 years of age * Patients planned for general anesthesia with an expected anesthetic time of at least 2 hours * Patients expected to receive postoperative opioid analgesia Exclusion Criteria: * Non-operative procedure (imaging) * Patients not admitted to the PACU postoperatively * Use of patient-controlled analgesia systems * Female patients who are pregnant or breastfeeding * Patients with asymmetric lung disease * American Society of Anesthesiologists (ASA) classification V * Emergency surgery (ASA E Modifier)

Study sites (1)

MI