A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years to 45 Years
- Sex
- Female only
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study follows healthy pregnant women with uncomplicated pregnancies who live at high altitude or sea level, during pregnancy and after birth. It compares how their hearts and lungs adjust, how their babies grow, and levels of nitric oxide, a substance that helps blood vessels work.
In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations \>3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Plan to give birth at a participating hospital above 3,500 meters or at sea level.
- Sign a form agreeing to take part in the study.
Who can't join
- Have certain existing heart, lung, or kidney diseases listed as CHD, COPD, or CKD, or have very severe limits on activity from heart disease (NYHA class above III).
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * women delivering at participating hospitals at more than 3500 meters or women delivering at participating hospitals at sea level * signed informed consent Exclusion Criteria: * preexisting cardiopulmonary pathologies (CHD, COPD, CKD, NYHA \> III)
Study sites (1)
MA
- Massachusetts General Hospital · Boston, MA 02114Lorenzo Berra, MD · Study contactMore trials in Boston