PREACTIVE: Preconditioning Exercise Intervention to Improve Symptoms and Quality of Life in Comorbid Atrial Fibrillation and HFpEF
PREACTIVE: Preconditioning With REsistance and AerobiC Training to ImproVe Exercise Intolerance and Quality of Life in Comorbid Atrial Fibrillation and HFpEF
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 60 Years to 99 Years
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
Atrial fibrillation (AF) and heart failure with preserved ejection fraction (HFpEF) are very common conditions that often occur together and result in worsening symptoms and reduced quality of life (QoL). Limitations being able to participate in activities of daily living is a primary complaint for AF-HFpEF patients, yet effective strategies to address this issue remain limited. While exercise interventions targeting aerobic training (AT) are recommended for patients with AF and HFpEF, unique challenges exist in this patient population who tend to be older. Specifically, many older patients with AF and HFpEF have muscle weakness, sarcopenia and frailty, that can make aerobic-focused exercise difficult and less tolerable. This study proposes that starting with progressive resistance training (PRT) before aerobic exercise may overcome these issues by improving muscle strength, making AT more manageable, and leading to better health outcomes. The goal of this study is to assess whether a sequential exercise program, named 'PREACTIVE' improves how people feel, decrease the amount of symptoms, and their ability to participate in exercise and activities. This study will specifically test a sequenced exercise approach of resistance training followed by aerobic exercise to improve symptoms, and quality of life in AF-HFpEF.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Official eligibility criteria
Inclusion Criteria: All participants will be age 60 and older, have a primary diagnosis of AF and HFpEF, based on electronic health record review. Patients with persistent AF or Paroxysmal AF are eligible. HFpEF will be defined in accordance to the 2022 AHA/ACC/HFSA Guideline using a clinical composite score, the H2FPEF score, in conjunction with diagnostic criteria below: * Ejection fraction ≥ 50% * E/e' ≥15 by Doppler Echocardiography * High H2FpEF score (≥5) * Must be in stable medical condition and able to begin an exercise program Exclusion Criteria: * Valvular heart disease as the primary etiology of heart failure (i.e., severe aortic stenosis or mitral regurgitation), * New York Heart Association Stage IV * Recent stroke (\<1 year) * Evidence or History of Cardiac amyloidosis * Patients with persistent AF and poor rate control (HR \> 110 at rest) * Significant change in cardiac medication or Heart Failure symptoms \< 2 weeks * Unstable or severe angina not controlled during daily activity by pharmacological therapy or at \<4 METS activity * Uncontrolled hypertension (defined as systolic blood pressure \>200 mm Hg and/or diastolic blood pressure\>110 mm Hg) with medications * Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions * Hospitalization or urgent care visit \< 4 weeks * Oxygen dependent Chronic Obstructive Pulmonary Disease (COPD) * Significant anemia (\<10 g/dL Hgb) * End stage renal replacement therapy associated with the need for dialysis * Active treatment for cancer defined as current radiation, chemotherapy, immunotherapy, or cancer recurrence within past 5 years * Hospice care and indication of life expectancy less than 2 years * Complete dependence confinement to a Wheelchair confinement or requiring a visual impairment or Orthopedic or severe musculoskeletal conditions that would prohibit resistance training or aerobic exercise. * Physician diagnosed Alzheimer's disease or Dementia or bipolar or psychotic disorder; Montreal Cognitive Assessment (MoCA) is ≤ 18 (based on participant screening) * High levels of physical functioning based the composite short physical performance battery score of ≥10 (out of 12) * Planned major surgery, coronary or leg revascularization during the next six months * Participation in a supervised exercise program or already engaging in regular exercise * Plans to transfer care outside of NU within the study period * Unable to consent or commit to requires study procedures * Non-English speaking
Study sites (1)
IL
- Northwestern University · Chicago, IL 60611More trials in Chicago