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Exercise Cardiovascular Magnetic Resonance In Heart Failure With Preserved Ejection Fraction

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 80 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests a low-field heart MRI during exercise, which takes pictures without entering the body. It aims to help find and describe heart failure with preserved pumping strength (HFpEF) and assess health risks in people who get short of breath with activity. People with HFpEF, people whose shortness of breath is not from HFpEF, and healthy volunteers may join.

The purpose of this study is to internally validate low-field Ex-CMR as a noninvasive tool for diagnosing, phenotyping, and risk stratifying HFpEF in patients with exertional dyspnea.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Give informed consent, meaning you agree to join after learning about the study.
  • Fit one of these three groups:
  • Have HFpEF confirmed by a heart doctor and the study leader, with the heart pumping out at least 50% of its blood with each beat.
  • Have shortness of breath, but exercise testing done inside the body showed you do not have HFpEF.
  • Be a healthy volunteer with no history of shortness of breath or trouble tolerating activity.

Who can't join

  • Cannot safely have a low-field heart MRI based on the MRI safety checklist.
  • Cannot or do not want to have a heart MRI during exercise.
  • Have a heart implant or replacement heart valve that makes the scan images unclear.
  • Were in the hospital for heart failure in the past 30 days.
  • Have frequent early heartbeats or an irregular heart rhythm that the study team thinks would harm scan quality or study comparisons.
  • Have a heart attack or unstable angina, which is chest pain from poor blood flow to the heart.
  • Have a planned procedure to restore blood flow in arteries of the heart, neck, or other parts of the body.
  • Have another cause of shortness of breath that the study leader rules out, such as certain heart muscle diseases, high blood pressure in lung arteries, lung disease worse than moderate, right-sided heart failure from lung disease, a complex heart defect present at birth, severe low red blood cells, or heart valve disease worse than moderate.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Informed consent obtained 2. Three groups will be enrolled: 1. HFpEF (cardiologist-adjudicated diagnosis as verified by PI, EF≥50%) 2. Non-cardiac dyspnea (patients have dyspnea but were found on invasive exercise testing not to have HFpEF). 3. Healthy volunteers with no history of dyspnea or effort intolerance. Exclusion Criteria: 1. Contraindication for low-field CMR, as indicated in MRI safety screening checklist (Research Document #1) 2. Patient inability or unwillingness to undergo Ex-CMR 3. Cardiac implants, mechanical or biological valve, causing artifacts that compromise the quality of data 4. Hospitalization for heart failure in the preceding 30 days. 5. Large R-R interval variation, caused by frequent premature ventricular contractions or non-sinus rhythms such as persistent atrial fibrillation, which, in the opinion of the investigators, compromises the quality of data acquisition, image analysis and disrupts the consistency of the cohorts 6. Myocardial infarction or unstable angina pectoris 7. Planned coronary, carotid, or peripheral artery revascularization 8. Other causes of dyspnea as indicated in patients' medical history based upon the opinion of the PI, such as restrictive cardiomyopathy or infiltrative conditions (e.g., amyloidosis), hypertrophic obstructive cardiomyopathy, primary pulmonary arterial hypertension, more than moderate chronic obstructive pulmonary disease, right heart failure due to pulmonary disease, complex congenital heart disease, severe anemia, or more than moderate mitral or aortic heart valve disease).

Study sites (1)

MN