Optic Nerve Head Strain in Non-glaucoma Subjects
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 30 Years to 90 Years
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study looks at how the optic nerve, which sends signals from the eye to the brain, changes after eye pressure is lowered. People without glaucoma will have eye pictures taken before and 2 weeks after starting a daily glaucoma eye drop, for comparison with people who have glaucoma. The eligibility list has conflicting rules about whether people with glaucoma can join.
Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Be over age 30.
- People of all sexes and ethnic groups may join.
- Have no history of open-angle glaucoma (OAG), a type of glaucoma.
- Have an eye exam by a glaucoma specialist that shows no signs of OAG.
- Have a normal OCT scan, which takes pictures of the nerve fiber layer at the back of the eye.
- The list also names optic neuropathy (optic nerve damage), suspected glaucoma, and glaucoma damage. These rules conflict with the rules requiring no glaucoma.
- Both eyes may be included if each meets the study rules.
Who can't join
- Cannot sit upright because of a physical disability.
- Have clouding, scars, cataracts, or bleeding inside the eye that prevents clear pictures, or cannot comfortably keep the eyes open for pictures.
- Cannot accurately measure eye pressure at home during the required skills check.
- Do not have reliable OCT eye scan results.
- Have any type of glaucoma.
- Have high myopia (strong nearsightedness), listed as a refractive error greater than -8.
- Have had vision-correction surgery on the cornea, or have a cornea condition that makes home eye pressure readings hard to interpret. The cornea is the clear front of the eye.
- Cannot understand English, or have a language or hearing impairment.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * Adults who have no history of OAG * Have an ocular examination by a glaucoma specialist with no indications of OAG * Have normal optical coherence tomography findings in the retinal nerve fiber layer. * Over age 30 will be included from * Both sexes * All ethnic groups. * Optic neuropathy. * Both suspects and those with glaucoma damage will be included. * When both eyes meet inclusion and exclusion criteria, both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual. Exclusion Criteria: * in whom sitting in an upright position is impossible due to physical disability * with ocular media opacity, corneal scarring, cataract or vitreous hemorrhage, that does not allow adequate imaging resolution. * in whom keeping the eyes open during the imaging procedure is not possible or uncomfortable. * who cannot perform home tonometry accurately at certification * who do not have reliable clinical Optical Coherence Tomography (OCT) testing. * with any form of glaucoma * with high myopia defined as refractive error \> -8 * with past keratorefractive surgery, corneal dystrophy, or corneal ectasia that would make self-tonometry measurements difficult to interpret * inability to understand English or with a language or hearing impairment
Study sites (1)
MD
- Johns Hopkins Hospital · Baltimore, MD 21287Harry Quigley · Study contact · 443-742-7079 · hquigley@jhmi.eduFarzaneh Dadvar · Study contact · 4103954535 · fdadvar1@jh.eduHarry A Quigley, MD · Principal investigatorMore trials in Baltimore