Finger Plethysmography to Predict Fluid Responsiveness in Healthy Pregnancy and Severe Preeclampsia
Finger Plethysmographic Cardiac Output Monitoring to Predict Fluid Responsiveness in Healthy Pregnancy and Women Diagnosed With Preeclampsia and Severe Features
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- Female only
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study tests whether a finger sensor can predict if extra fluid would help the heart pump more blood during pregnancy. It compares the sensor with a heart ultrasound. It is for women with severe preeclampsia, a serious pregnancy condition involving high blood pressure, and healthy women near their due date.
The goal of this observational study is to determine whether noninvasive finger plethysmographic cardiac output monitoring can help predict fluid responsiveness in pregnant women, including those with preeclampsia with severe features. The main questions it aims to answer are : * Can changes in cardiac output measured by finger plethysmography predict fluid responsiveness? * How does this method perform compared with standard echocardiographic assessment? Participants will provide consent and undergo noninvasive hemodynamic monitoring and a brief reversible physiological challenge.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Women with severe preeclampsia diagnosed using medical guidelines.
- Healthy pregnant women at full term, such as those planning a C-section.
Who can't join
- Cannot give written consent, or choose to leave the study.
- Body mass index (BMI), a measure based on height and weight, over 40.
- Pregnant with twins or more babies, or 22 weeks pregnant or less.
- Baby’s heart rate pattern raises concern, or an emergency C-section is needed.
- History of long-term high blood pressure, long-term kidney disease, or heart disease.
- Diabetes, a past stroke, or chronic obstructive pulmonary disease (COPD), a long-term lung disease.
- Cannot tolerate having the legs raised into the study position.
- Cannot get clear enough heart ultrasound images through the chest.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * Women diagnosed with preeclampsia with severe features following ACOG recommendations (systolic/diastolic BP \>160/110 mmHg, proteinuria, or other severe features like headaches, visual disturbances, kidney/liver impairment, thrombocytopenia). * Healthy pregnant women at term (for comparison group, e.g., scheduled for elective Cesarean delivery). Exclusion Criteria: * Patients who can not provide written consent to participate in the study * BMI greater than 40 kg/m² * Multiple pregnancy (twins, triplets, etc.) * Non-reassuring fetal heart tracing * ≤ 22 weeks gestation * History of chronic arterial hypertension * Chronic kidney disease * Congenital or known acquired heart disease * Chronic obstructive pulmonary disease * Diabetes * History of stroke * Not tolerating passive leg raising (unable to be placed in the required study position) * No TTE-windows * Withdrawing consent * Emergency cesarean delivery
Study sites (1)
CA
- Lucile Packard Children's Hospital · Palo Alto, CA 94304More trials in Palo Alto