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IMPACT-HTN Study of Patients With Hypertension

Prospective Early Patient Experience Initiative (IMPACT-HTN)

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

An estimated 120 million people have high blood pressure (hypertension) in the US, of which approximately 10% have resistant hypertension. This study aims to enroll patients who continue to have hypertension while being treated with at least two medications. The study will follow patients for approximately 3 months and collect real-world information on changes in their health to identify an ideal patient profile that would benefit from 4th-line antihypertensive therapies, including, but not limited to, FDA-approved aprocitentan, renal denervation, mineralocorticoid receptor antagonists, etc.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * Signed and dated informed consent form * Ability to answer survey questions and to report blood pressure reading monthly * Male and female participants; 18 years or older * Treated with at least 2 antihypertensive therapies of different pharmacological classes for at least 4 weeks before the screening visit * Mean Sitting Systolic Blood Pressure (SiSBP) greater or equal to 130 mmHg Exclusion Criteria: * Confirmed severe hypertension (grade 3) defined as SiSBP greater than or equal to 180 mmHg and/or Sitting Diastolic Blood Pressure (SiDBP) greater than or equal to 110 mmHg * Clinically significant unstable cardiac disease at screening or in the past in the opinion of the investigator * Heart failure NYHA functional class III and IV or NT-proBNP \> 500 pg/mL * Severe renal insufficiency or eGFR \< 15 mL/min/1.73m2 * Moderate to severe hepatic impairment (Child-Pugh B and C) or elevated aminotransferase (\> 3 x ULN)

Study sites (2)

CA

NC