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Periodontal Inflammation and Epigenetics in Obese Individuals

Association Between Epigenetic Changes, Periodontal Microbiota, And Periodontal Inflammation in Obese Individuals

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 75 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at long-term changes in how genes work in adults with periodontitis, a disease that causes gum swelling and damage. It compares people with and without obesity before and after deep cleaning of the teeth and gums, without surgery.

The goal of this study is to investigate the long-term changes in host epigenetic modifications in obese individuals with periodontitis. The aims of the study are: • To monitor longitudinal changes in host epigenetic modifiers following non-surgical periodontal therapy in periodontitis patients Study subjects would be categorized into two groups, non-obese with periodontitis, and obese with periodontitis. The study will primarily evaluate changes among these groups cross-sectionally, then longitudinally following non-surgical periodontal therapy (deep cleaning) to determine if any changes occur with treatment.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Age 18 or older.
  • No gum disease treatment in the past 6 months.
  • Do not use tobacco.
  • No history of pregnancy, breastfeeding, or use of birth control medicine.
  • Have at least 20 teeth.

Who can't join

  • Used medicine to fight germs or viruses in the past 3 months.
  • Have a history of uncontrolled diabetes, rheumatoid arthritis (a disease that causes joint swelling), or osteoporosis (weak bones).
  • Have a history of mouth cancer.
  • Currently use hormonal birth control.
  • Are pregnant or breastfeeding now, or were in the past 6 months.
  • Currently take weight loss medicine.
  • Plan to have weight loss surgery during the study.
  • Have another condition or treatment known to affect swelling or the mix of germs in the mouth.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Adults aged ≥18 years, * No history of periodontal therapy in the last 6 months, * No use of tobacco, * No history of pregnancy lactation or contraceptive medication. * Need to have a minimum of 20 teeth. Exclusion Criteria: * Had antimicrobial/antiviral therapy in the previous 3 months, * History of uncontrolled diabetes, * History of rheumatoid arthritis, * History of osteoporosis, * History of oral cancer, * Currently taking hormonal contraception, * If pregnant or lactating currently or prior 6 months, * Subjects on current weight loss drugs * If planning weight reduction surgery during the time of the study * Any other condition, disease or therapy with documented influence on oral inflammation and/or oral microbial environment.

Study sites (1)

LA