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The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication

The Effects of Strength Training on Muscle Mass and Mental Health in Adults Taking Obesity Medication: A Pilot Study

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 3 months
  • Procedures mentioned: Questionnaires

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "This includes: * Orientation session to explain study protocol, exercise program, and complete questionnaire about participants' medical history and lifestyle. * Two health assessments at baseline and at 3 months."
  • "After the 3-month period, individuals in the control group may choose to participate in the exercise training and complete the optional 6-month assessments. * Personalized resistance exercise sessions for 60 minutes per session, twice per week, for 3 months."
  • "After the 3-month period, participants may choose to participate in the optional exercise program, which includes 60 min/session, all for 2 sessions/week for 3 months."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This 3-month study tests whether strength training, such as lifting weights, helps adults keep muscle and supports mental health while starting GLP-1 medicines for obesity. It is for adults who are not active and meet the study’s weight and health rules. The exercise group has personalized, 60-minute training sessions twice a week.

The purpose of this study is to examine the effects of resistance exercise, such as weightlifting, on retention of muscle mass and mental health in individuals taking GLP-1 RAs (an obesity medication). Resistance exercise is focused on increasing the strength of participants' muscles, such as how much participant can lift. •The duration of this study is 3 months. This includes: * Orientation session to explain study protocol, exercise program, and complete questionnaire about participants' medical history and lifestyle. * Two health assessments at baseline and at 3 months. These assessments include body composition, resting blood pressure, cardiovascular function, and muscular strength. Both the resistance exercise group and the control group will complete assessments at baseline and again at 3 months. After the 3-month period, individuals in the control group may choose to participate in the exercise training and complete the optional 6-month assessments. * Personalized resistance exercise sessions for 60 minutes per session, twice per week, for 3 months.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Age 18 or older.
  • Starting a GLP-1 medicine prescribed by a health care provider, and willing to wait until after the first study health check to start it.
  • Do not smoke.
  • Have a body mass index (BMI, a measure of weight compared with height) of 30–45, or a BMI of at least 27 with high blood pressure or sleep apnea (breathing that stops and starts during sleep).
  • Have not met U.S. exercise guidelines over the past 6 months.
  • Can do the study’s required exercises.

Who can't join

  • Serious heart problems or major heart disease risk factors, such as blood pressure of 160/100 or higher that is not controlled; muscle or bone problems that limit exercise; or another condition that threatens life or could make exercise unsafe.
  • Cancer needing treatment in the past 5 years; an underactive or overactive thyroid; or a personal or family history of medullary thyroid cancer or MEN2, a condition that can cause tumors in hormone-making glands.
  • Slow stomach emptying; long-term pancreas inflammation or sudden pancreas inflammation with no known cause; liver disease or liver scarring; or type 1 or type 2 diabetes.
  • Alcohol or drug misuse, including at least 4 drinks a day or 8 a week for women, at least 5 drinks a day or 15 a week for men, or a score of 3 or higher on the study’s drug-use screening test.
  • Past eating disorders or weight-loss surgery; weight gain or loss of 5% or more in the past 6 months; or use of obesity medicine in the past 3 months.
  • Past major depression or other severe mental health disorders, including a “yes” answer to question 9 on the study’s PHQ-9 mood survey; or inability to give informed consent (understand and agree to join).
  • Plan to be away for 2 weeks or more in the next 3 months, or are in another clinical trial testing a treatment or program.
  • Are pregnant or plan to become pregnant during the study.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Initiating GLP-1 RAs prescribed by physician or advanced practice practitioner and willing to withhold the start of the drug until baseline assessment completed * Non-Smoker * ≥18 years old * Obese: Body Mass Index 30-45 kg/m² or BMI ≥27 + ≥1 weight related comorbidity; either hypertension or sleep apnea confirmed by participant self-report * Inactive: not meeting the current US exercise guidelines over the past 6 months * Capable of performing the required exercise training Exclusion Criteria: * A serious heart condition, such as unstable heart disease or heart failure, irregular heartbeats that are not well controlled, severe narrowing of the heart valves, or any recent inflammation of the heart or its lining * Cancer requiring treatment in the past 5 years * Hypothyroidism/hyperthyroidism * Personal or family history of Medullary Thyroid Carcinoma (MTC) or Multiple Endocrine Neoplasia Syndrome type 2 (MEN2) * Gastroparesis * Chronic/idiopathic acute pancreatitis * Hepatic disease or cirrhosis * Struggle with alcohol or other substance abuse (heavy drinking (≥4 drinks/day or ≥8 drinks/week for women; ≥5 drinks/day or ≥15 drinks/week for men), or who score ≥3 on the Drug Abuse Screening Test (DAST-10)) * Diabetes (Type 1 or 2) * Major risk factors for coronary heart disease such as uncontrolled high blood pressure (≥160 mm Hg systolic or ≥100 mm Hg diastolic) * Problems with your muscles or bones that limit your ability to exercise * Any other medical condition that is life-threatening, can interfere with or be aggravated by the exercise training * Plans to be away ≥2 weeks in the next 3 months * Participation in any other concurrent interventional clinical trial * History of eating disorders or weight-loss surgery, unstable weight (±5% change in past 6 months), or use of obesity medication (e.g., such as Wegovy, Ozempic, Saxenda, Zepbound, Mounjaro) in the last 3 months * Inability to give informed consent * History of major depression or other severe psychiatric disorders (e.g., who answer "yes" to question 9 on PHQ-9 in the Psych\_QoL\_Sleep questionnaires.) * Pregnant or plan to become pregnant during study

Study sites (1)

PA