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Assessing Follow up Trajectories in Eating, Routines, and Weight After GLP-1

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Mentioned in the study description

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Questionnaires

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "All participants will receive a Bluetooth scale to track weight from home and will complete short online questionnaires several times over the year."
Compensation
Mentioned in the study description
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether an online lifestyle program helps adults keep weight off after stopping a GLP-1 medicine, such as semaglutide or tirzepatide. It is for adults who stopped the medicine less than 30 days ago. The study lasts 12 months, is done from home, and assigns people by chance to the online program or usual care.

Many people who use GLP-1 medications (such as semaglutide or tirzepatide) achieve meaningful weight loss, but maintaining that weight loss off after stopping the medication can be very challenging. Researchers at Tufts University are conducting a study to learn whether a digital lifestyle program can help people maintain their weight loss after they stop taking a GLP-1 medication. Adults who have recently stopped a GLP-1 medication may be eligible to participate. Participants will be randomly assigned to either receive access to a digital program or to continue with usual care. The study lasts 12 months and is fully remote. All participants will receive a Bluetooth scale to track weight from home and will complete short online questionnaires several times over the year. By taking part, participants can help researchers better understand how to support long-term weight maintenance in a way that is affordable, accessible, and sustainable. Participants are compensated for their time, and involvement may help improve care for others with similar experiences.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Age 18 or older, with no upper age limit.
  • Can read, write, and speak English, Spanish, or both.
  • Can understand the study and agree to take part.
  • Stopped taking a GLP-1 medicine less than 30 days ago.
  • Willing to take part.

Who can't join

  • Did not lose a meaningful amount of weight while taking a GLP-1 medicine, such as losing less than 5% of body weight.
  • Have a major mental health condition, problems with thinking or memory, or substance misuse that could make taking part difficult.
  • Have a condition that greatly affects weight or makes taking part unsafe. Examples include pregnancy, breastfeeding, recent weight-loss surgery, current use of weight-loss medicines, or hormone disorders that affect weight.
  • Cannot use a smartphone or complete study tasks from home.
  • Are in another weight-loss program, weight-maintenance program, or clinical trial that researchers think would interfere.
  • Cannot understand the study and agree to take part because of problems with thinking or memory.
  • Are under the state's legal care or guardianship.
  • Are younger than 18.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * 18 years of age or older (no upper limit); * ability to read, write, and speak English and/or Spanish; * ability to provide informed consent; * less than 30-days since GLP-1 RA cessation; * willing to participate. Exclusion Criteria: * No clinically significant weight loss (e.g., \< 5% body weight) while taking GLP medication; * major psychiatric illness, cognitive impairment, or substance misuse that could impair ability to participate; * medical conditions that significantly affect weight or make participation unsafe (e.g., pregnancy or breastfeeding, recent bariatric surgery, current use of GLP 1 or other anti-obesity medications, or endocrine disorders that alter weight regulation); * inability to use a smartphone or complete remote study procedures; * participation in another weight loss or maintenance program or clinical trial judged by investigators to interfere with study involvement; * Adults unable to consent (cognitively impaired); * Wards of the state; * Anyone under age 18.

Study sites (1)

MA