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Antidepressant Therapy for Improved Blood Vessel Health After Preeclampsia

Role of Antidepressant Therapy to Improve Vascular Function After Preeclampsia

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 45 Years
Sex
Female only
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether medicine for depression can improve blood vessel health after preeclampsia, a pregnancy condition that causes high blood pressure and other problems. It is for women ages 18–24 who had a pregnancy 12 weeks to 5 years ago, with or without preeclampsia and with or without depression.

Preeclampsia is a condition in pregnancy where a woman develops high blood pressure and other complications. Women who develop preeclampsia are 4 times more likely to have heart disease later in life. They are also more likely to have depression after pregnancy. Why they are more likely to develop these conditions is not known. It may be because their blood vessels were damaged during pregnancy. Changes in blood vessel health can predict heart disease. These changes have been recorded after pregnancy in women who had preeclampsia. These changes have also been recorded in women who have depression. In the previous phase of this award, we found that women who had preeclampsia in pregnancy had changes in blood vessel health after pregnancy. We also found that if these women were taking a medicine to treat depression, their blood vessel health was normal. This could mean that treatment for depression can also increase blood vessel health in women who had preeclampsia. In this project we will study how changes in blood vessel health are related to preeclampsia and depression in women who have had both. We will also study how medicine to treat depression can improve blood vessel health after preeclampsia. We will do this by measuring how blood vessels work in women who have had preeclampsia compared to women who did not, and in women who have depression and women who do not. This will tell us more about why risk for depression and heart disease is higher in women who have had preeclampsia. It will also help us understand if medicine for depression can reduce cardiovascular disease risk after preeclampsia.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Are 18–24 years old.
  • Had a pregnancy 12 weeks to 5 years ago.
  • Had either a normal pregnancy or a pregnancy with preeclampsia. You may have depression now or not have depression.

Who can't join

  • Have a history of heart or blood vessel disease, skin disease, or a disease that affects how your body uses food for energy.
  • Use or have ever used tobacco, nicotine, or e-cigarettes.
  • Had diabetes during pregnancy.
  • Take medicine for high blood pressure or to lower cholesterol.
  • Are pregnant now.
  • Are allergic to materials used in the study, such as latex.
  • Have a known allergy to the study drugs.
  • Currently take an SSRI, a type of medicine for depression.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * 18-24 years old, * 12 weeks - 5 years post pregnancy * one of the following: * history of a normal pregnancy with a current diagnosis of depression, * history of a normal pregnancy without a current diagnosis of depression, * history of a preeclamptic pregnancy with a current diagnosis of depression * history of preeclamptic pregnancy without a current diagnosis of depression. Exclusion Criteria: * history of cardiovascular, metabolic, and/or skin diseases * current or history of tobacco/nicotine/ e-cigarette use * history of gestational diabetes * current antihypertensive or cholesterol-lowering medication * currently pregnant * allergy to materials used during the experiment (e.g. latex), * known allergy to study drugs * currently using SSRI medications

Study sites (1)

IA