Biofluid Research on Age-Related or Inherited Neurodegeneration
Biofluid Research on Age-Related or Inherited Neurodegeneration (BRAIN)
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study collects and stores blood, genetic material (DNA or RNA), family history, and other personal details to help study diseases that damage the brain and nerves over time. It is for adults with these diseases, their family members, and adults with no known brain or nerve disease. Researchers aim to learn more about the genes and other factors linked to these diseases.
The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with age-related neurodegenerative conditions, or their family members who may or may not be at risk for similar conditions. This study will continue to further expand research into the molecular and genetic basis of these diseases and their risk factors.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- People diagnosed with a disease that damages the brain or nerves over time, such as Alzheimer's disease, Parkinson's disease, or ALS.
- People thought to have dementia (problems with memory or thinking) or a movement disorder caused by this type of disease, even if the cause is unknown.
- Family members of people described above, whether or not they have symptoms or a known risk of a similar disease.
- People with no known brain or nerve disease, to provide information for comparison.
Who can't join
- Anyone under age 18.
- Anyone with a condition or situation that the study doctor thinks could affect the study results or make it much harder to take part. This may include brain or nerve conditions, mental health conditions, heart conditions, infections, or conditions involving brain or nerve surgery.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: 1. People with a clinical diagnosis of a neurodegenerative disease including, but not limited to Alzheimer's disease (AD), Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), progressive supranuclear palsy (PSP), primary progressive aphasia (PPA), limbic-predominant age-related TDP-43 encephalopathy (LATE), corticobasal syndrome (CBS), posterior cortical atrophy (PCA), primary lateral sclerosis (PLS), primary muscular atrophy (PMA), or individuals with a suspected neurodegenerative dementia and/or movement disorder of unknown etiology will be considered for enrollment 2. Family Members of individuals who meet the criteria of group 1, who are people who may or may not be at risk for a similar neurodegenerative disease, who may or may not be symptomatic, and who may or may not have known or unknown genetic risk. 3. People with no known neurological disease who will provide control data. Exclusion Criteria: 1. Anyone who is under the age of 18. 2. Anyone with a condition or in a situation which, in the investigator's opinion, could confound the study findings or may interfere significantly with a person's participation, including but not limited to neurological, psychological, and other medical conditions (such as cardiac, neurosurgical, infectious conditions).
Study sites (1)
PA
- University of Pennsylvania · Philadelphia, PA 19104Cara Joyce, MPH · Study contact · 267-271-0740 · cara.joyce@pennmedicine.upenn.eduEmily Xie · Study contact · emily.xie@pennmedicine.upenn.eduCorey McMillan, PhD · Principal investigatorMore trials in Philadelphia