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Digital Outreach for Heart Failure Adherence

Adherence Through Digital Health: Evaluating Randomized Engagement in Heart Failure

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 12 months

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Members will remain assigned to their randomized strategy for 12 months."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether text messages or automated phone calls help adults with heart failure refill overdue medicines and take them as prescribed. It compares this outreach with usual care and also looks at health outcomes.

The goal of the ADHERE-HF study is to evaluate whether care-embedded, operationally delivered digital outreach improves medication refill, adherence, and clinical outcomes among adults with heart failure who are overdue for a refill of an eligible guideline-directed medical therapy (GDMT) medication. The main question it aims to answer is: Does digital outreach using interactive text messages or automated telephone calls increase short-term refill of overdue heart failure medications compared with usual care? The study will evaluate the effectiveness of a digital outreach strategy delivered through existing health system communication channels. Members who have opted in to pharmacy text messaging will receive interactive text messages, while those who have not opted in will receive an interactive automated telephone call. The comparison group will receive usual care with no additional outreach.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 18 or older.
  • You have an active KPNC health plan membership.
  • Your heart failure was recorded at least 6 months before the study’s reference date. Your record includes an ejection fraction (EF), which measures how much blood your heart pumps out with each beat.
  • You have been prescribed at least one eligible heart failure medicine for at least 6 months.
  • If your EF is 50% or higher, eligible medicines are sacubitril/valsartan, an MRA, or an SGLT2 inhibitor. These are types of heart failure medicines.
  • If your EF is below 50%, eligible medicines also include an ACE inhibitor, an ARB, or certain beta-blockers: bisoprolol, carvedilol, or sustained-release metoprolol succinate.
  • At least one eligible medicine refill is still unfilled and is 7–13 days overdue on the study’s reference date.

Who can't join

  • You have a recorded allergy to, or cannot tolerate, all eligible medicines with overdue refills.
  • You receive hospice care or care focused on comfort.
  • You stayed in a skilled nursing facility in the past 12 months.
  • You have no valid phone number on file where you can receive texts or automated calls.
  • You chose not to receive Kaiser Permanente pharmacy outreach about taking medicines as prescribed.
  • You have other conditions that prevent outreach.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: 1. Age ≥18 years 2. Active KPNC membership 3. Heart failure diagnosis documented at least 6 months before the index date, with a documented EF 4. Prescribed at least one eligible GDMT medication for ≥6 months: 1. HFpEF (EF≥50%): ARNI (sacubitril/valsartan); MRA; SGLT2i 2. HFrEF or HFmrEF (EF \<50%): ARNI (sacubitril/valsartan), ACEi, or ARB; Beta-blocker (bisoprolol, carvedilol, or sustained-release metoprolol succinate); MRA; SGLT2i 5. At least one unfilled refill for an eligible GDMT medication that is 7-13 days overdue at index Exclusion Criteria: 1. Documented allergy or intolerance to all eligible GDMT medications for which the patient is overdue 2. Receiving hospice or comfort-focused care 3. Skilled nursing facility stay within prior 12 months 4. No valid telephone number on file through which the patient could be reached by text message or automated telephone call 5. Opted out of receiving pharmacy medication adherence outreach from Kaiser Permanente 6. Other conditions that prevent outreach

Study sites (1)

CA