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Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension (Beta2AR).

Beta-2 Adrenergic Receptor Polymorphic Variants: An Endotype of Salt Sensitive Hypertension.

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 50 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Mentioned in the study description

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Mentioned in the study description
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at whether forms of the B2AR gene and the amount of salt people eat work together to cause high blood pressure. It is for adults ages 18–50 who have high blood pressure and take no more than two medicines for it.

All living things are made of building blocks called cells. Genes are the part of cells that contain the instructions which determine important things about you, like your height or hair color, and affect your health. DNA is the material in the cells that makes up your genes and your particular make-up is call your genotype. Changes or differences in a gene (your genotype) may affect your chances of developing a particular disease, or how a person responds to a particular drug. Your genes are passed down from your parents and then passed on to your children. Different forms of certain genes in your body, for example, the B2AR gene, can increase your blood pressure. The form of the gene that could raise your blood pressure is called the risk allele or risk genotype. Taking too much salt in your food or drink also can increase your blood pressure. In this research study we want to determine if different forms of the B2AR gene and the level of salt intake act together to cause high blood pressure.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • You are 18–50 years old.
  • Your main doctor has diagnosed you with high blood pressure.
  • You take no more than two blood pressure medicines.
  • Your kidney, liver, thyroid, blood cell count, body chemistry, and salt and mineral tests are normal.

Who can't join

  • You are pregnant.
  • You have kidney, nerve, or heart disease other than high blood pressure.
  • You have diabetes.
  • Your high blood pressure is caused by another health condition, based on your health history, exam, and blood and urine tests.
  • You take medicines other than blood pressure medicines or thyroid hormone replacement.
  • You have used birth control pills, birth control implants, or estrogen replacement therapy within two years of the study.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Ages 18-50 years; HTN as defined by the primary physician; on ≤ two anti-hypertensives; normal renal, liver, metabolic, electrolyte, CBC, and thyroid tests. Exclusion Criteria: * Pregnancy; renal, neurologic, and cardiac diseases other than HTN; diabetes; secondary HTN as assessed by history, physical examination, screening blood and urine tests; any drug therapy, except for anti-hypertensives and replacement thyroid medication; and no oral contraceptives/implants/ERT within 2 years of study.

Study sites (1)

MA