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Post-exercise Blood Pressure With Inorganic Nitrate

Effects of Inorganic Nitrate Supplementation on Post-exercise Hypotension Response Following Acute Exercise in Young Adults With Elevated Body Mass Index and Blood Pressure

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 40 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether drinking beetroot juice with inorganic nitrate before one exercise session changes blood pressure more than exercise alone. It is for adults ages 18–40 who get little exercise, have obesity, and have a resting top blood pressure number of at least 120.

This study is examining whether acute inorganic nitrate supplementation in the form of beetroot juice, paired with an acute bout of exercise, affects blood pressure and what is the magnitude of the difference compared to exercise alone.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Are willing and able to follow study steps and attend visits.
  • Are male or female and ages 18–40.
  • Get less than 150 minutes of moderate aerobic exercise each week, or do not exercise regularly.
  • Have a resting systolic blood pressure—the top number—of at least 120 mmHg.
  • Have a BMI of at least 30 and a waist size of at least 94 cm for males or 80 cm for females. BMI is a measure based on height and weight.
  • Can ride a stationary exercise bike without help.
  • Have had no changes to your medication plan for the past 6 months.
  • Can stop eating nitrate-rich foods during the study, including beets, arugula, spinach, celery, and grapefruit.

Who can't join

  • Have a BMI of 29.9 or lower, lost about 3 kg in the past 3 months, or take weight-loss drugs.
  • Have smoked within the past 5 years.
  • Have an injury, doctor's restriction, or health condition that prevents hard exercise. Listed conditions include uncontrolled blood pressure of 140/90 or higher, diabetes, past heart attack or stroke, heart or blood vessel disease, lung or kidney disease, diseases affecting how the body uses energy, or other sudden or unstable illness.
  • Use any hormone replacement, or have had surgery to remove the uterus or ovaries.
  • Take or took any of these drugs in the past 4 weeks: calcium channel blockers, statins, ACE or renin inhibitors, angiotensin receptor blockers, organic nitrates such as nitroglycerin, alpha- or beta-blockers, diuretics (water pills), proton pump inhibitors (acid reducers), PDE-5 inhibitors such as Cialis or Viagra, or xanthine oxidase inhibitors such as allopurinol.
  • Used antibiotics taken by mouth in the past 4 weeks, or use antibacterial mouthwash, including chlorhexidine mouthwash, and will not stop using it.
  • Have mouth cancer or severe mouth disease.
  • Are pregnant or planning pregnancy, are a child or prisoner, have problems with thinking or understanding, or do not speak English. Fetuses and newborns are also excluded.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Willingness and ability to comply with scheduled visits and study procedures. * Males and females, ages 18-40 years old * Sedentary (\<150 minutes of moderate intensity aerobic exercise per week, or not engaged in a regular exercise program at all * Resting systolic BP ≥ 120 mmHg. * BMI ≥ 30 kg/m2 * Waist circumference ≥94 cm for males and ≥80 cm for females * Be able to perform exercise on a cycle ergometer without assistance * Stable medication regimen for the last 6 months * Be able to discontinue the use of inorganic nitrate rich foods such as beets, arugula, spinach, celery, and grapefruit throughout the duration of the study. Exclusion Criteria: * Body mass index ≤ 29.9 Kg/m2 * Smoker within last 5 years * Has experienced significant weight loss \~3 kg in the last three months or taking any weight loss drugs * Current medical condition that prohibits exercising at high intensities * Currently on hormone replacement of any kind * History of medical conditions that would prohibit high intensity exercise, such as:, uncontrolled hypertension (≥140/90), diabetes, myocardial infarction, cerebrovascular event, known cardiovascular, pulmonary, renal, metabolic diseases, and acute or unstable disease other than high BMI and waist circumference * Current injuries that would prohibit exercising on a stationary bike * Currently restricted by medical doctor to engage in exercise * Currently taking or have taken any of the following medications in the last 4 weeks (calcium channel blockers, statins, ACE or renin inhibitors, angiotensin receptor blockers, organic nitrates (e.g., nitroglycerine, alpha- or beta-blockers, diuretics, proton pump inhibitors, PDE-5 inhibitors (e.g., Cialis, Viagra), or xanthine oxidase inhibitors (e.g., Allopurinol)) * Oral antibiotic use within previous four weeks including over-the-counter antibacterial mouthwash or a mouthwash containing chlorhexidine and unwilling to discontinue use * Oral cancer/severe oral disease * Had hysterectomy or oophorectomy * Pregnant women or planning to be pregnant, Fetuses, neonates, children, prisoners, cognitively impaired, non-English speaking participants

Study sites (1)

VA