A Study of EloraTZP in Adult Participants With Obesity or Overweight and Type 2 Diabetes
A Phase 3 Study to Investigate the Efficacy and Safety of LY900043 in Adult Participants With Obesity or Overweight and Type 2 Diabetes
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
In plain language
This study compares EloraTZP, a mix of eloralintide and tirzepatide, with tirzepatide alone to see how safely and well it helps people lose weight. It is for adults with obesity or overweight who have type 2 diabetes. Taking part lasts about 2 years.
The purpose of this study is to investigate the efficacy and safety of eloralintide and tirzepatide coformulation (EloraTZP) compared to tirzepatide for body weight reduction in participants with obesity or overweight and type 2 diabetes. Participation in the study will last about 2 years.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Who can join
- Have type 2 diabetes.
- Report that your weight changed by less than 5% in the 90 days before screening.
- Have a BMI of 27 or higher at screening. BMI is a measure based on height and weight.
- Report trying at least one diet to lose weight that did not work.
Who can't join
- Have had or plan to have surgery for obesity. Liposuction, fat freezing, or a tummy tuck is allowed if done more than 1 year before screening.
- Have had or plan to have a procedure using a scope or a medical device to treat obesity or type 2 diabetes. Past device treatment is allowed if the device was removed more than 6 months before screening.
- Have type 1 diabetes.
- Used insulin, DPP-4 inhibitors, or medicines that act on amylin, GLP-1, or GIP within 90 days before screening. These include certain diabetes medicines and specially mixed versions.
- Within 90 days before screening, had a heart attack, stroke, a procedure to restore blood flow to the heart, unstable angina (heart-related chest pain), or a hospital stay for heart failure.
- Have or have had Class IV heart failure, the most severe class of a condition in which the heart does not pump well enough.
- Used medicines or alternative remedies meant for weight loss within 90 days of screening.
Simplified for readability. The official criteria below are what the study team uses.
Official eligibility criteria
Inclusion Criteria: * Have type 2 diabetes * Have a stable self-reported body weight (\<5% body weight change) for 90 days prior to screening * Have a BMI of ≥27 kg/m2 at screening * Have a history of at least 1 self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity and/or type 2 diabetes (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes * Have taken any of the following within 90 days prior to screening * medications with direct amylin, glucagon-like peptide-1 (GLP-1) or glucagon-dependent insulinotropic polypeptide (GIP) receptor activity, including compounded therapies * dipeptidyl peptidase 4 (DPP-4) inhibitors, and * insulin * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening
Study sites (25)
AZ
- Tucson Clinical Research Institute · Tucson, AZ 85712Girish Karamchandani · Principal investigatorMore trials in Tucson
CA
- Pacific Clinical Studies Inc. · Los Alamitos, CA 90720 · Study contact · 562-598-0600 ext 205Etsegenet Ayele · Principal investigatorMore trials in Los Alamitos
- Los Angeles Institute for Metabolic Research · Los Angeles, CA 90015 · Study contact · 213-373-8380Juan Frias · Principal investigatorMore trials in Los Angeles
CO
- University of Colorado Anschutz Medical Campus · Aurora, CO 80045 · Study contact · 303-724-9005Daniel Bessesen · Principal investigatorMore trials in Aurora
FL
- American Research Centers of Florida · Pembroke Pines, FL 33027 · Study contact · 9542373799Nora Bassam Khoury · Principal investigatorMore trials in Pembroke Pines
- Encore Medical Research - Weston · Weston, FL 33331 · Study contact · 954-777-8827Sandro Bacchelli · Principal investigatorMore trials in Weston
GA
- Care Access - Dalton - Clinical Trials Center by Walmart & Care Access · Dalton, GA 30720 · Study contact · 877-791-0656Chukwukanene Ofiaeli · Principal investigatorMore trials in Dalton
HI
- Pacific Diabetes & Endocrine Center · Honolulu, HI 96817 · Study contact · 8085260303ALAN PARSA · Principal investigatorMore trials in Honolulu
IN
- DM Clinical Research - Indianapolis · Indianapolis, IN 46254 · Study contact · 463-271-3050Brandon Essink · Principal investigatorMore trials in Indianapolis
LA
- Care Access - Eunice · Eunice, LA 70535 · Study contact · 3374578841Randall Miller · Principal investigatorMore trials in Eunice
- Tandem Clinical Research · Marrero, LA 70072 · Study contact · 504-934-8424Adil Fatakia · Principal investigatorMore trials in Marrero
MO
- Care Access - St. Louis · St Louis, MO 63131Anthony Margherita · Principal investigatorMore trials in St Louis
NJ
- IMA Clinical Research Warren · Warren Township, NJ 07059Samar Hameed · Principal investigatorMore trials in Warren Township
NY
- NYC Research · New York, NY 10016 · Study contact · 516-574-9232Anastasios Manessis · Principal investigatorMore trials in New York
- IMA Clinical Research NYC Midtown · New York, NY 10036Eli Shalenberg · Principal investigatorMore trials in New York
TX
- IMA Clinical Research Austin · Austin, TX 78745 · Study contact · 5126490082Nomita Kim · Principal investigatorMore trials in Austin
- Diabetes and Thyroid Center of Ft. Worth · Fort Worth, TX 76132 · Study contact · 8172630007Anjanette Tan · Principal investigatorMore trials in Fort Worth
- Juno Research · Houston, TX 77040 · Study contact · 713-779-5494Damaris Vega · Principal investigatorMore trials in Houston
- Care Access - Houston - Clinical Trials Center by Walmart & Care Access · Houston, TX 77082 · Study contact · 877-791-0656Ali Bajwa · Principal investigatorMore trials in Houston
- ERA Health Research-Texas · Midland, TX 79707 · Study contact · 4325287555Sapna Chilka · Principal investigatorMore trials in Midland
- Texas Valley Clinical Research (TVCR) - Mission · Mission, TX 78572Alejandro Gonzalez Campos · Principal investigatorMore trials in Mission
- IMA Clinical Research San Antonio · San Antonio, TX 78229 · Study contact · 210-692-7157Lisa Blair · Principal investigatorMore trials in San Antonio
- Care Access - Tyler - Clinical Trials Center by Walmart & Care Access · Tyler, TX 75704 · Study contact · 877-791-0656Alphonse Ekole · Principal investigatorMore trials in Tyler
VA
- Washington Center for Weight Management and Research · Arlington, VA 22206 · Study contact · 7038070037Domenica Rubino · Principal investigatorMore trials in Arlington
WA
- Eastside Research Associates · Redmond, WA 98052 · Study contact · (425) 869-6828Christopher Price · Principal investigatorMore trials in Redmond