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EXercise-induced PhysioLogical Adaptations In Neurological Disorders

Exercise Testing for Neurological Conditions

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: Blood draws, MRI scans, Heart tracing (ECG)

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Participants will take part in a single, one-day study visit and will be asked to: * Perform a standardized exercise test on a bicycle ergometer * Undergo a brain MRI (magnetic resonance imaging) scan, a blood draw, and autonomic measurements before and after the exercise test"
  • "During exercise, continuous electrocardiography (ECG) and respiratory gas measurements (spiroergometry) will be recorded to assess maximal oxygen consumption (VO2max) and other measures of exercise capacity and response."
  • "Before and after the exercise test, participants will undergo magnetic resonance imaging (MRI) to assess structural and functional brain measures as well as neurochemical and metabolic markers."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests how one exercise session affects brain function in adults with certain brain or nerve conditions compared with healthy adults. At one study visit, participants will ride an exercise bike. Before and after exercise, they will have a brain MRI scan, a blood draw, and tests of automatic body functions.

The goal of this study is to investigate how a one-time exercise session influences different parameters of brain function in people with neurological diseases compared to healthy volunteers. The main questions the study aims to answer are: * How do fitness level, exercise performance, and physical exhaustion differ between patients with neurological diseases and healthy participants? * How does acute exercise affect brain function and other physiological biomarkers in participants with neurological diseases? Participants will take part in a single, one-day study visit and will be asked to: * Perform a standardized exercise test on a bicycle ergometer * Undergo a brain MRI (magnetic resonance imaging) scan, a blood draw, and autonomic measurements before and after the exercise test

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Be 18 years or older.
  • For the brain or nerve condition group: have a diagnosis of epilepsy (a seizure disorder), functional neurological disorder (problems with how the nervous system works), mild cognitive impairment (mild memory or thinking problems), dementia, Parkinson’s disease, concussion, or a brain tumor.
  • For the healthy group: have no diagnosed brain or nerve disease.

Who can't join

  • Do not speak English.
  • Have a condition that makes exercise unsafe or prevents using the exercise bike, such as a current infection, severe heart disease, uncontrolled high blood pressure, or seizures linked to exercise.
  • Take medicine to control heart rhythm or heart rate.
  • Cannot safely have an MRI scan, such as because of an electrical implant, metal implants or objects that react to magnets, or pregnancy.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * 18 years or older * Clinical diagnosis of one of the following neurological diseases: epilepsy, functional neurological disorder, mild cognitive impairment, dementia, Parkinson's disease, concussion, brain tumor \[for participants with neurological diseases\] * No diagnosis of neurological disease \[for healthy control participants\] Exclusion Criteria: * Non-english speaking individuals * Exercise contraindications (e.g., physical impairments limiting use of bicycle ergometer, acute infections, severe heart disease, uncontrolled hypertension, exercise associated seizures) * Current use of medications for cardiac rhythm or rate control * Magnetic resonance imaging (MRI) contraindications (e.g., electrical implants, ferromagnetic implants or objects, pregnancy)

Study sites (1)

MA