A Study of Eloralintide (LY3841136) in Participants With Obesity or Overweight, Type 2 Diabetes, and Increased Cardiovascular Risk
A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study to Investigate the Efficacy and Safety of Once-Weekly Eloralintide in Adult Participants With Obesity or Overweight, Type 2 Diabetes, and Increased CV Risk
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 45 Years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
Not stated in the study description — ask the study team about visits and procedures.
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
The main purpose of this study is to evaluate the efficacy and safety of eloralintide compared with a placebo in participants with obesity or overweight, type 2 diabetes, and increased cardiovascular risk.
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Official eligibility criteria
Inclusion Criteria: * Have type 2 diabetes * Have a HbA1c value between ≥ 6.5% and ≤ 9.5% at screening * Are on stable treatment with an unchanged dose of at least 1 and no more than 4 antihyperglycemic therapies for at least 90 days before screening * Have an increased risk of cardiovascular events * Have a BMI ≥ 25.0 kg/m2 at screening * Have a stable body weight (\<5% body weight change) for 90 days prior to screening * Have a history of at least one self-reported unsuccessful dietary effort to reduce body weight Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed \>1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes * Have a history or diagnosis of New York Heart Association Functional Classification IV congestive heart failure * Have had within 60 days prior to screening: * acute myocardial infarction * stroke * hospitalization for congestive heart failure, or * coronary, peripheral, or carotid artery revascularization procedure * Have received treatment combining sulfonylurea and insulin within 90 days prior to screening
Study sites (70)
AL
- Central Research Associates · Birmingham, AL 35205 · Study contact · 2053271077David Pendley · Principal investigatorMore trials in Birmingham
- University of Alabama - Department of Nutrition Sciences · Birmingham, AL 35294 · Study contact · 205-996-4733William Garvey · Principal investigatorMore trials in Birmingham
- Nephrology Consultants · Huntsville, AL 35805 · Study contact · 2565334626Michael Quadrini · Principal investigatorMore trials in Huntsville
AZ
- Smiths Medical Center · Apache Junction, AZ 85120 · Study contact · 404-585-8358Paul Olorunfemi · Principal investigatorMore trials in Apache Junction
- Prime Medical Group, LLC dba Gilbert Center for Family Medicine, LLC · Gilbert, AZ 85296 · Study contact · 480-691-2213Sunildat Maheshwari · Principal investigatorMore trials in Gilbert
- Elite Clinical Studies, LLC · Phoenix, AZ 85018 · Study contact · 602-788-3437Joseph Lillo, DO · Principal investigatorMore trials in Phoenix
- Southwest Kidney Institute - Surprise · Surprise, AZ 85374 · Study contact · (480) 610-6100Minesh Rajpal · Principal investigatorMore trials in Surprise
CA
- Valley Clinical Trials, Inc. · Covina, CA 91723 · Study contact · 310-309-9491Linda Glaser · Principal investigatorMore trials in Covina
- Neighborhood Healthcare Institute of Health · Escondido, CA 92025 · Study contact · 7607376984Cheryl Thompson · Principal investigatorMore trials in Escondido
- First Valley Medical Group · Lancaster, CA 93534 · Study contact · 661-948-6011Kanagaratnam Sivalingam · Principal investigatorMore trials in Lancaster
- Ark Clinical Research · Long Beach, CA 90815 · Study contact · 5629971000Apinya Vutikullird · Principal investigatorMore trials in Long Beach
- Valley Clinical Trials, LLC dba Flourish Research · Northridge, CA 91325 · Study contact · 818-280-4220Christopher Chow · Principal investigatorMore trials in Northridge
- FOMAT Medical Research · Oxnard, CA 93030 · Study contact · 805-483-1185Augusto Focil · Principal investigatorMore trials in Oxnard
- Acclaim Clinical Research · San Diego, CA 92120 · Study contact · (858) 299-0009Mitch Biermann · Principal investigatorMore trials in San Diego
- Care Access - Santa Clarita · Santa Clarita, CA 91321 · Study contact · 661-371-7272Sina Tebi · Principal investigatorMore trials in Santa Clarita
- Millennium Clinical Trials · Westlake Village, CA 91361 · Study contact · 805-496-3322Razmig Krumian · Principal investigatorMore trials in Westlake Village
CT
- Chase Medical Research, LLC · Waterbury, CT 06708 · Study contact · 2034194420Joseph Soufer · Principal investigatorMore trials in Waterbury
FL
- Omega Research Orlando · Altamonte Springs, FL 32714 · Study contact · 386-668-4202Kwabena Ayesu · Principal investigatorMore trials in Altamonte Springs
- Care Access - Brandon · Brandon, FL 33510 · Study contact · 813-582-7224Parenkumar Patel · Principal investigatorMore trials in Brandon
- American Research Institute · Cutler Bay, FL 33157Manuel Garcia Estrada · Principal investigatorMore trials in Cutler Bay
- Fleming Island Center for Clinical Research · Fleming Island, FL 32003 · Study contact · 9046210390Jennifer Sidey · Principal investigatorMore trials in Fleming Island
- Northeast Research Institute - Downtown Office · Jacksonville, FL 32204 · Study contact · 904-541-8225David Sutton · Principal investigatorMore trials in Jacksonville
- Lakeview Institute of Clinical Research · Leesburg, FL 34748 · Study contact · 352-782-0606Khai Chang · Principal investigatorMore trials in Leesburg
- Millennium Medical Research - Miami · Miami, FL 33126 · Study contact · 7869538858Aurelio Ortiz · Principal investigatorMore trials in Miami
- Onhealth Research Center · Miami, FL 33186Jimena Blandon · Principal investigatorMore trials in Miami
- Center for Diabetes, Obesity, and Metabolism · Pembroke Pines, FL 33024 · Study contact · 754-888-9122Rodolfo Galindo · Principal investigatorMore trials in Pembroke Pines
- Peace River Cardiovascular Center · Port Charlotte, FL 33952 · Study contact · 941-629-5356David Hotchkiss · Principal investigatorMore trials in Port Charlotte
GA
- Southeastern Clinical Research Institute · Augusta, GA 30904 · Study contact · 7069223005Matthew Diamond · Principal investigatorMore trials in Augusta
HI
- East-West Medical Research Institute · Honolulu, HI 96814 · Study contact · 8085316886Cindy Pau · Principal investigatorMore trials in Honolulu
IL
- Care Access - Arlington Heights · Arlington Heights, IL 60005 · Study contact · 877-791-0656Peta-Gay Jackson Booth · Principal investigatorMore trials in Arlington Heights
- Healthcare Research Network - Chicago · Tinley Park, IL 60477 · Study contact · 7083382245Ronald Stumbris · Principal investigatorMore trials in Tinley Park
IN
- American Health Network of Indiana, LLC - Franklin · Franklin, IN 46131 · Study contact · 317-718-5479George Cornett · Principal investigatorMore trials in Franklin
- American Health Network of Indiana, LLC - Greenfield · Greenfield, IN 46140 · Study contact · (317)462-1825Andrew Daluga · Principal investigatorMore trials in Greenfield
MA
- Lucida Clinical Trials · New Bedford, MA 02740 · Study contact · 508-720-2015David Shih · Principal investigatorMore trials in New Bedford
MD
- Care Access - Baltimore · Baltimore, MD 21213 · Study contact · 877-791-0656Peta-Gay Jackson Booth · Principal investigatorMore trials in Baltimore
- Ascension Saint Agnes Heart Care · Baltimore, MD 21229 · Study contact · 443-798-2670Jeffrey Cole · Principal investigatorMore trials in Baltimore
MI
- Lake Michigan Nephrology · Saint Joseph, MI 49085 · Study contact · 269-428-0819Oliver Songlingco · Principal investigatorMore trials in Saint Joseph
- Revive Research Institute, Inc. · Southfield, MI 48075 · Study contact · 248-829-3103Syed Raza · Principal investigatorMore trials in Southfield
MO
- Clinvest Headlands Llc · Springfield, MO 65807 · Study contact · 4178837889Cory Bethmann · Principal investigatorMore trials in Springfield
MS
- SKY Integrative Medical Center/SKYCRNG · Ridgeland, MS 39157 · Study contact · 601-567-1321Bob Hutchins · Principal investigatorMore trials in Ridgeland
NC
- West Clinical Research · Morehead City, NC 28557 · Study contact · 2525150050Patrick Morgante · Principal investigatorMore trials in Morehead City
- Trial Management Associates - Wilmington - Floral Parkway · Wilmington, NC 28403William Jones · Principal investigatorMore trials in Wilmington
NH
- Southern Nh Diabetes and Endocrinology · Nashua, NH 03063 · Study contact · 603-577-7574John Poremba · Principal investigatorMore trials in Nashua
NV
- DaVita Clinical Research - Las Vegas · Las Vegas, NV 89107 · Study contact · 7028771887MARK VISHNEPOLSKY · Principal investigatorMore trials in Las Vegas
- Excel Clinical Research, LLC · Las Vegas, NV 89109 · Study contact · 7026801500Robby Quintos · Principal investigatorMore trials in Las Vegas
NY
- Rochester Clinical Research, LLC · Rochester, NY 14609 · Study contact · 585-288-0890Patrick Connors · Principal investigatorMore trials in Rochester
OH
- Kidney and Hypertension Center · Cincinnati, OH 45212 · Study contact · 513-861-0800James Davis · Principal investigatorMore trials in Cincinnati
OR
- The Corvallis Clinic, P.C. · Corvallis, OR 97330Daniel Barrett · Principal investigatorMore trials in Corvallis
PA
- Clinical Renal Associates, Ltd. · Exton, PA 19341 · Study contact · 6108728501Chike Okechukwu · Principal investigatorMore trials in Exton
- Clinical Renal Associates Ltd. · Media, PA 19063 · Study contact · 610-872-8501Heather Mascio · Principal investigatorMore trials in Media
RI
- Nephrology Associates - East Providence · East Providence, RI 02914 · Study contact · 401-438-5950Michael Thursby · Principal investigatorMore trials in East Providence
TX
- Amarillo Medical Specialists · Amarillo, TX 79124 · Study contact · 806-358-8331William Biggs · Principal investigatorMore trials in Amarillo
- Renal Disease Research Institute · Dallas, TX 75246 · Study contact · 2143666125Bernard Fischbach · Principal investigatorMore trials in Dallas
- Headlands Research-El Paso · El Paso, TX 79902 · Study contact · (915) 910 7088Ryan Casey · Principal investigatorMore trials in El Paso
- Valley Institute of Research - Fort Worth · Fort Worth, TX 76164 · Study contact · 8176257733Alex Guevara · Principal investigatorMore trials in Fort Worth
- Biopharma Informatic, LLC · Houston, TX 77043 · Study contact · (281) 944-3610Syed Humayun Naqvi, MD · Principal investigatorMore trials in Houston
- Research Physicians Network, LLC · Houston, TX 77089 · Study contact · 2819443610Amir Hassan · Principal investigatorMore trials in Houston
- Quality First Family Health/SKYCRNG · Humble, TX 77396 · Study contact · 2818354449Eli Newsome · Principal investigatorMore trials in Humble
- DCOL Center for Clinical Research · Longview, TX 75605 · Study contact · 903-238-8854Kathleen Harris · Principal investigatorMore trials in Longview
- Biopharma Informatic, LLC · McAllen, TX 78503 · Study contact · 2819443610Gloria Ortiz, MD · Principal investigatorMore trials in McAllen
- Revival Research Institute, LLC · McKinney, TX 75071Syed Saghir · Principal investigatorMore trials in McKinney
- Renal Specialists of Houston · Pasadena, TX 77504 · Study contact · 713-947-9507Vijay Koka · Principal investigatorMore trials in Pasadena
- Clinical Advancement Center · San Antonio, TX 78212 · Study contact · 210-223-4444Pablo Pergola · Principal investigatorMore trials in San Antonio
- Medrasa Clinical Research · Wylie, TX 75098 · Study contact · 469-449-3645Tanvir Ahmad · Principal investigatorMore trials in Wylie
UT
- Advanced Research Institute · Ogden, UT 84405 · Study contact · 801-409-2040Michael Woolman · Principal investigatorMore trials in Ogden
VA
- Virginia Nephrology Group · Arlington, VA 22205Renuka Sothinathan · Principal investigatorMore trials in Arlington
- Care Access - Arlington 2 · Arlington, VA 22206 · Study contact · 877-791-0656Chih Chao Yang · Principal investigatorMore trials in Arlington
- York Clinical Research · Norfolk, VA 23504 · Study contact · 757-373-8478Charles Lovell · Principal investigatorMore trials in Norfolk
- Dominion Medical Associates, Inc. · Richmond, VA 23219 · Study contact · 8042492111Richard Jackson · Principal investigatorMore trials in Richmond
WA
- Eastside Research Associates · Redmond, WA 98052 · Study contact · (425) 869-6828Christopher Price · Principal investigatorMore trials in Redmond