Clinical trials in Springfield, MO

34 recruiting studies have a site in or near Springfield, MO, Missouri.

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Showing 34 of 34 studies

RecruitingPhase 3NCT06345729

A Study of Calderasib (MK-1084) Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004/KANDLELIT-004)

Sponsor: Merck Sharp & Dohme LLC

Kansas City, MO · Springfield, MO · +13 more sites

RecruitingPhase 3NCT07654374

A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Chesterfield, MO · City of Saint Peters, MO · Hazelwood, MO · +71 more sites

RecruitingPhase 3NCT03150693

Inotuzumab Ozogamicin and Frontline Chemotherapy in Treating Young Adults With Newly Diagnosed B Acute Lymphoblastic Leukemia

Sponsor: Alliance for Clinical Trials in Oncology

Ballwin, MO · Bolivar, MO · Branson, MO · +452 more sites

RecruitingPhase 3NCT04267848

Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])

Sponsor: National Cancer Institute (NCI)

Ballwin, MO · Bolivar, MO · Branson, MO · +1147 more sites

RecruitingPhase 3NCT07674654

A Long-Term Safety Study of Elismetrep (K-304) in the Acute Treatment of Migraine

Sponsor: Kallyope Inc.

City of Saint Peters, MO · Hazelwood, MO · Kansas City, MO · +110 more sites

RecruitingPhase 3NCT06989112

DESTINY-Endometrial01: A Phase III Study of Trastuzumab Deruxtecan Plus Rilvegostomig or Pembrolizumab as First-Line Treatment of HER2-Expressing (IHC 3+/2+), Mismatch Repair Proficient (pMMR) Endometrial Cancer

Sponsor: AstraZeneca

Springfield, MO · St Louis, MO · +61 more sites

RecruitingPhase 3NCT07351045

A Clinical Study to Evaluate the Effects of Enicepatide (RO7795068) in Participants With Obesity or Overweight Without Type 2 Diabetes

Sponsor: Hoffmann-La Roche

Springfield, MO · +43 more sites

RecruitingNot applicableNCT06911632

Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension

Sponsor: Tempus AI

Hannibal, MO · Springfield, MO · +38 more sites

RecruitingPhase 3NCT07174336

A Study of Tersolisib (LY4064809/STX-478) With Other Anti-Cancer Treatments in Participants With Advanced Breast Cancer With a Genetic Change (PIK3CA)

Sponsor: Eli Lilly and Company

Kansas City, MO · Springfield, MO · +127 more sites

RecruitingPhase 2NCT07589608

A Study to Investigate Weight Management With Macupatide and Eloralintide, Alone or in Combination, in Adult Participants With Obesity or Overweight

Sponsor: Eli Lilly and Company

City of Saint Peters, MO · Springfield, MO · +38 more sites

RecruitingPhase 3NCT07794579

A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity

Sponsor: Eli Lilly and Company

Springfield, MO · +79 more sites

RecruitingPhase not listedNCT03998202

Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer

Sponsor: Wake Forest University Health Sciences

Cape Girardeau, MO · Farmington, MO · Rolla, MO · +144 more sites

RecruitingPhase 3NCT06119581

A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer

Sponsor: Eli Lilly and Company

Springfield, MO · +86 more sites

RecruitingPhase 2NCT06143956

A Master Protocol Study (LY900038) of Multiple Intervention-Specific-Appendices (ISAs) in Adult Participants With Obesity or Overweight

Sponsor: Eli Lilly and Company

City of Saint Peters, MO · Springfield, MO · +48 more sites

RecruitingPhase 3NCT07228832

Phase III Study of Ivonescimab or Bevacizumab Combined With FOLFOX in Patients With Metastatic Colorectal Cancer

Sponsor: Summit Therapeutics

Springfield, MO · +111 more sites

RecruitingPhase 2NCT05673148

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

Sponsor: Alliance for Clinical Trials in Oncology

Columbia, MO · Farmington, MO · Saint Joseph, MO · +185 more sites

RecruitingNot applicableNCT07283939

Studying the PAGODA Algorithm for Chemotherapy Dose Changes to Prevent Unplanned Treatment Delays

Sponsor: Alliance for Clinical Trials in Oncology

Ballwin, MO · Bolivar, MO · Branson, MO · +357 more sites

RecruitingPhase 3NCT04649242

Randomized Study in Children and Adolescents With Migraine: Acute Treatment

Sponsor: Pfizer

Ozark, MO · Springfield, MO · +167 more sites

RecruitingPhase 3NCT04743141

Long-term Safety Study of Rimegepant in Pediatric Subjects for the Acute Treatment of Migraine

Sponsor: Pfizer

Ozark, MO · Springfield, MO · +113 more sites

RecruitingPhase 2NCT07415954

A Research Study Comparing How Well Different Doses of the Medicine NNC0662-0419 Lower Blood Sugar in People With Type 2 Diabetes

Sponsor: Novo Nordisk A/S

Springfield, MO · +22 more sites

RecruitingPhase not listedNCT07211178

Evaluating Minimal Residual Disease (MRD) Through Longitudinal Circulating Tumor DNA (ctDNA) Profiling in Breast Malignancies

Sponsor: Tempus AI

Springfield, MO · +15 more sites

RecruitingPhase 3NCT05879926

Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression Plus Endocrine Therapy in Premenopausal Patients With pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score Less Than or Equal to 25

Sponsor: NRG Oncology

Ballwin, MO · Bolivar, MO · Branson, MO · +1223 more sites

RecruitingPhase 3NCT07645924

A Study to Evaluate the Efficacy and Safety of Elismetrep (K-304) in the Acute Treatment of Migraine

Sponsor: Kallyope Inc.

City of Saint Peters, MO · Hazelwood, MO · Kansas City, MO · +110 more sites

RecruitingPhase 3NCT04423211

Treating Prostate Cancer That Has Come Back After Surgery With Apalutamide and Targeted Radiation Based on PET Imaging

Sponsor: ECOG-ACRIN Cancer Research Group

Bolivar, MO · Cape Girardeau, MO · +338 more sites

RecruitingPhase 3NCT05812807

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

Sponsor: Alliance for Clinical Trials in Oncology

Ballwin, MO · Cape Girardeau, MO · City of Saint Peters, MO · +825 more sites

RecruitingPhase 3NCT06748222

E-Mindfulness Approaches for Living After Breast Cancer

Sponsor: NRG Oncology

Osage Beach, MO · Saint Joseph, MO · Springfield, MO · +378 more sites

RecruitingPhase 3NCT06641466

A Study to Learn About the Study Medicine Called Rimegepant in Women When Used for Intermittent Prevention of Menstrual Migraine

Sponsor: Pfizer

Springfield, MO · Weldon Spring, MO · +30 more sites

RecruitingPhase not listedNCT07327489

Predicting Response to Immunotherapy From Analysis of Live Tumor Biopsies (ELEPHAS-05)

Sponsor: Elephas

Springfield, MO · St Louis, MO · +5 more sites

RecruitingPhase 2 / Phase 3NCT03851445

Lung-MAP: A Master Screening Protocol for Previously-Treated Non-Small Cell Lung Cancer

Sponsor: SWOG Cancer Research Network

Ballwin, MO · Bonne Terre, MO · Cape Girardeau, MO · +1226 more sites

RecruitingPhase 3NCT04852887

De-Escalation of Breast Radiation Trial for Hormone Sensitive, HER-2 Negative, Oncotype Recurrence Score Less Than or Equal to 18 Breast Cancer (DEBRA)

Sponsor: NRG Oncology

Cape Girardeau, MO · City of Saint Peters, MO · Columbia, MO · +809 more sites

RecruitingPhase not listedNCT05236114

GEMINI-NSCLC: NSCLC Biomarker Study

Sponsor: Tempus AI

Joplin, MO · Osage Beach, MO · Springfield, MO · +55 more sites

RecruitingPhase not listedNCT06073431

LOTUS-CC: An Observational Research Study to Uncover Subtypes of Cancer Cachexia

Sponsor: University of Rochester

Farmington, MO · Osage Beach, MO · Sainte Genevieve, MO · +222 more sites

RecruitingPhase 3NCT05929768

Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

Sponsor: SWOG Cancer Research Network

Ballwin, MO · Bolivar, MO · Branson, MO · +952 more sites

RecruitingPhase not listedNCT05234177

Tempus CRC Surveillance Study: A ctDNA Biomarker Profiling Study of Patients With CRC Using NGS Assays

Sponsor: Tempus AI

Joplin, MO · Springfield, MO · St Louis, MO · +17 more sites

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.