RecruitingPhase 1NCT04222413
Metarrestin (ML-246) in Subjects With Metastatic Solid Tumors
Sponsor: National Cancer Institute (NCI)
Fairway, KS · Bethesda, MD
Phase 1 Colorectal Cancer clinical trials
74 recruiting Phase 1 colorectal cancer studies in the US. What trial phases mean
Other phases
RecruitingPhase 1NCT04847063
Individual Response to Hyperthermic Intraperitoneal Chemotherapy (HIPEC) Treatment of Peritoneal Carcinomatosis From Peritoneal Mesothelioma or Atypical Mesothelial Proliferation or From Ovarian, Colorectal, or Appendiceal Histologies
Sponsor: National Cancer Institute (NCI)
Bethesda, MD
RecruitingPhase 1NCT06885697
Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma
Sponsor: National Cancer Institute (NCI)
Bethesda, MD
RecruitingPhase 1NCT07878988
This is a Phase 1/1b Study to Evaluate the Safety and Preliminary Antitumor Activity of LTZ-232 in Participants With Advanced/Metastatic Colorectal Cancer and Other Solid Tumors
Sponsor: LTZ Therapeutics, Inc.
Scottsdale, AZ
RecruitingPhase 1NCT07594067
TCR1188-ABC Cells in KRAS-mutated Cancers
Sponsor: University of Pennsylvania
Philadelphia, PA
RecruitingPhase 1NCT07094204
A Study to Find a Suitable Dose of ASP5834 in Adults With Solid Tumors
Sponsor: Astellas Pharma Inc
Santa Monica, CA · Atlanta, GA · Jefferson, LA · +8 more sites
RecruitingPhase 1NCT07261631
Phase I Study of [177Lu]Lu-DFC413 in Patients With Solid Tumors
Sponsor: Novartis Pharmaceuticals
Princeton, NJ
RecruitingPhase 1NCT06400472
A Study of Sofe-M in Participants With Selected Advanced Solid Tumors
Sponsor: Eli Lilly and Company
Scottsdale, AZ · La Jolla, CA · Atlanta, GA · +8 more sites
RecruitingPhase 1NCT07114601
A Study of LY4257496 in Participants With Cancer (OMNIRAY)
Sponsor: Eli Lilly and Company
Duarte, CA · Santa Monica, CA · Stanford, CA · +13 more sites
RecruitingPhase 1NCT04429542
Study of Safety and Tolerability of BCA101 Monotherapy and in Combination Therapy in Patients With EGFR-driven Advanced Solid Tumors
Sponsor: Bicara Therapeutics
La Jolla, CA · Los Angeles, CA · +12 more sites
RecruitingPhase 1NCT07416552
A Study to Investigate CEA-PRIT 2.0 in Participants With Metastatic Colorectal Cancer (mCRC)
Sponsor: Hoffmann-La Roche
Chicago, IL · St Louis, MO · Omaha, NE · +2 more sites
RecruitingPhase 1NCT07454642
AVA6103 in Subjects With Locally Advanced or Metastatic Selected Solid Tumors
Sponsor: Avacta Life Sciences Ltd
Scottsdale, AZ · Sarasota, FL · Chicago, IL · +4 more sites
RecruitingPhase 1NCT07544589
A Phase 1 Study Evaluating DISP-10 in Participants With Advanced Gastrointestinal Cancers
Sponsor: Dispatch Biotherapeutics
Duarte, CA · Newport Beach, CA · Tampa, FL · +4 more sites
RecruitingPhase 1NCT06270706
A Phase 1 Study of PLN-101095 in Adults With Advanced or Metastatic Solid Tumors
Sponsor: Pliant Therapeutics, Inc.
New Haven, CT · Atlanta, GA · Grand Rapids, MI · +13 more sites
RecruitingPhase 1NCT07085091
A First in Human Study of ALX2004 With Advanced or Metastatic Selected Solid Tumors
Sponsor: ALX Oncology Inc.
La Jolla, CA · Santa Monica, CA · Tampa, FL · +9 more sites
RecruitingPhase 1NCT05877599
A Study of NT-175 in Adult Participants With Advanced Malignancies That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
Sponsor: AstraZeneca
Gilbert, AZ · Duarte, CA · Los Angeles, CA · +17 more sites
RecruitingPhase 1NCT07578571
A Phase 1 Study of IM-1617 in Participants With Advanced Cancer
Sponsor: Immunome, Inc.
New Haven, CT · Sarasota, FL · Boston, MA · +1 more sites
RecruitingPhase 1NCT06004245
A Study to Evaluate the Safety, Pharmacokinetics, and Anti-Tumor Activity of VVD-133214 as Monotherapy and in Combination in Participants With Advanced Solid Tumors
Sponsor: Vividion Therapeutics, Inc.
Tucson, AZ · Duarte, CA · Irvine, CA · +13 more sites
RecruitingPhase 1NCT06218914
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
Sponsor: AstraZeneca
Duarte, CA · Los Angeles, CA · Newport Beach, CA · +15 more sites
RecruitingPhase 1NCT06663319
A Study of JNJ-89402638 for Metastatic Colorectal and Gastric Cancers
Sponsor: Janssen Research & Development, LLC
Tucson, AZ · Aurora, CO · Sarasota, FL · +3 more sites
RecruitingPhase 1NCT07277270
A Study of GSK5764227 in Combination With Standard of Care (SoC) or Other Agents in Participants With Advanced Solid Tumors
Sponsor: GlaxoSmithKline
Reunion, FL · New Hyde Park, NY · Philadelphia, PA · +2 more sites
RecruitingPhase 1NCT07229313
A Study of KIVU-107 in Participants With Locally Advanced or Metastatic Solid Tumors
Sponsor: Kivu Bioscience Inc.
Santa Monica, CA · New Have, CT
RecruitingPhase 1NCT07020117
A Study of [225Ac]Ac-AKY-1189 in Patients With Solid Tumors
Sponsor: Aktis Oncology, Inc.
Duarte, CA · Irvine, CA · Miami, FL · +11 more sites
RecruitingPhase 1NCT07487168
Safety and Efficacy of PIPAC Using Single Agent Mitomycin in Solid Tumors
Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Tampa, FL
RecruitingPhase 1NCT07217171
A Study Evaluating the Safety, Efficacy, and Pharmacokinetics (PK) of EVOLVE104 in Participants With Advanced Urothelial and Squamous Cell Carcinomas
Sponsor: EvolveImmune United, Inc
Duarte, CA · Los Angeles, CA · San Francisco, CA · +13 more sites
RecruitingPhase 1NCT07812805
SKL35501 With SKL35502 Imaging in Adults With NTSR1 Positive Advanced Solid Tumors
Sponsor: SK Life Science, Inc.
Glen Burnie, MD · Pittsburgh, PA
RecruitingPhase 1NCT06440005
A Study to Evaluate Safety, Tolerability and Preliminary Activity of AGX101 in Participants With Advanced Solid Tumors
Sponsor: Angiex, Inc.
Los Angeles, CA · Sarasota, FL · St Louis, MO · +4 more sites
RecruitingPhase 1NCT07216105
FT836 With or Without Chemotherapy and/or Monoclonal Antibodies, in Participants With Advanced Solid Tumors
Sponsor: Fate Therapeutics
La Jolla, CA · Los Angeles, CA · Minneapolis, MN · +2 more sites
RecruitingPhase 1NCT04329494
PIPAC for the Treatment of Peritoneal Carcinomatosis in Patients With Ovarian, Uterine, Appendiceal, Colorectal, or Gastric Cancer
Sponsor: City of Hope Medical Center
Duarte, CA · Jacksonville, FL · Greenlawn, NY
RecruitingPhase 1NCT07321106
A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Anti-tumor Activity of CBI-1214 T Cell Engager in Participants With Advanced or Metastatic MSS/MSI-L Colorectal Cancer
Sponsor: Cartography Biosciences
Phoenix, AZ · Duarte, CA · Los Angeles, CA · +7 more sites
RecruitingPhase 1NCT06586515
MOONRAY-01, A Study of LY3962673 in Participants With KRAS G12D-Mutant Solid Tumors
Sponsor: Eli Lilly and Company
Duarte, CA · Santa Monica, CA · Denver, CO · +22 more sites
RecruitingPhase 1NCT06225011
Fluoxetine for the Modification of Colorectal Tumor Immune Cells Before Surgery in Patients With Colorectal Cancer
Sponsor: Jonsson Comprehensive Cancer Center
Los Angeles, CA
RecruitingPhase 1NCT07066657
A Study of MRG007 (ARR-217) in Patients With Advanced Solid Tumors
Sponsor: ArriVent BioPharma, Inc.
Los Angeles, CA · San Francisco, CA · Aurora, CO · +7 more sites
RecruitingPhase 1NCT06242470
A Study of MGC026 in Participants With Advanced Solid Tumors
Sponsor: MacroGenics
Los Angeles, CA · Grand Rapids, MI · Lake Success, NY · +4 more sites
RecruitingPhase 1NCT06910657
IDOV-Immune for Advanced Solid Tumors
Sponsor: ViroMissile, Inc.
St Louis, MO · Houston, TX · San Antonio, TX
RecruitingPhase 1NCT05433142
Study of XmAb®819 in Subjects With Advanced Clear Cell Renal Cell Carcinoma
Sponsor: Xencor, Inc.
Phoenix, AZ · Duarte, CA · Sacramento, CA · +17 more sites
RecruitingPhase 1NCT06562192
Phase I Study of [177Lu]Lu-NNS309 in Patients With Pancreatic, Lung, Breast and Colorectal Cancers
Sponsor: Novartis Pharmaceuticals
Birmingham, AL · Los Angeles, CA · Palo Alto, CA · +6 more sites
RecruitingPhase 1NCT06764771
A Study of BMS-986488 as Monotherapy and Combination Therapy in Participants With Advanced Malignant Tumors
Sponsor: Bristol-Myers Squibb
Hackensack, NJ · Allentown, PA · Germantown, TN · +1 more sites
RecruitingPhase 1NCT06974110
Study of Orally Administered MOMA-341 in Participants With Advanced or Metastatic Solid Tumors
Sponsor: MOMA Therapeutics
Phoenix, AZ · San Diego, CA · Tampa, FL · +6 more sites
RecruitingPhase 1NCT07500298
Phase 1 Study Of SAR445877 In Combination With FOLFOX6 And Bevacizumab As First-Line Treatment For Microsatellite Stable Metastatic Colorectal Cancer
Sponsor: M.D. Anderson Cancer Center
Houston, TX
RecruitingPhase 1NCT06179160
A Study to Evaluate INCB161734 in Participants With Advanced or Metastatic Solid Tumors With KRAS G12D Mutation
Sponsor: Incyte Corporation
Phoenix, AZ · Palo Alto, CA · Santa Monica, CA · +10 more sites
RecruitingPhase 1NCT06834126
Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial
Sponsor: City of Hope Medical Center
Duarte, CA
RecruitingPhase 1NCT07318805
A Study to Learn About the Study Medicine Called PF-08032562 in People With Advanced or Metastatic Solid Tumors
Sponsor: Pfizer
Duarte, CA · Grand Rapids, MI · Long Island City, NY · +10 more sites
RecruitingPhase 1NCT06657144
A Study of CHS-114 (Tagmokitug) in Combination With Toripalimab and/or Other Treatments in Participants With Advanced Solid Tumors
Sponsor: Coherus Oncology, Inc.
Tucson, AZ · Duarte, CA · Aurora, CO · +17 more sites
RecruitingPhase 1NCT07337525
A First in Human Study of PLT012 in Participants With Solid Tumor Cancers
Sponsor: Pilatus Biosciences Inc
Los Angeles, CA · Dallas, TX · Houston, TX · +1 more sites
RecruitingPhase 1NCT07300150
A Study of PT0511 in Participants With KRAS Mutated or Amplified Advanced Solid Tumors
Sponsor: PAQ Therapeutics, Inc.
Boston, MA · San Antonio, TX · +2 more sites
RecruitingPhase 1NCT04678648
A Trial of RSC-1255 for Treatment of Patients With Advanced Malignancies
Sponsor: RasCal Therapeutics, Inc.
Los Angeles, CA · Denver, CO · Nashville, TN
RecruitingPhase 1NCT07503808
A Study of IDE034 in Adult Participants With Locally Advanced/Metastatic Solid Tumors Types
Sponsor: IDEAYA Biosciences
Denver, CO · Sarasota, FL · Detroit, MI · +12 more sites
RecruitingPhase 1NCT07540572
A Study to Investigate the Safety, Pharmacokinetics, and Preliminary Efficacy of IDE574 Therapy in Adult Participants With Advanced Solid Tumors
Sponsor: IDEAYA Biosciences
Plantation, FL · East Brunswick, NJ · Lake Success, NY · +8 more sites
RecruitingPhase 1NCT06756035
CT-95 in Advanced Cancers Associated With Mesothelin Expression
Sponsor: Context Therapeutics Inc.
Denver, CO · Chicago, IL · Grand Rapids, MI · +6 more sites
Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.