Phase 2 Colorectal Cancer clinical trials

51 recruiting Phase 2 colorectal cancer studies in the US. What trial phases mean

Other phases

RecruitingPhase 2NCT07595874

Neoadjuvant Botensilimab and Balstilimab for the Treatment of Advanced Resectable Colorectal Cancer NEST3

Sponsor: City of Hope Medical Center

Goodyear, AZ · Corona, CA · Duarte, CA · +8 more sites

RecruitingPhase 2NCT01174121

Immunotherapy Using Tumor Infiltrating Lymphocytes for Patients With Metastatic Cancer

Sponsor: National Cancer Institute (NCI)

Bethesda, MD

RecruitingPhase 2NCT07023289

A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease

Sponsor: AbbVie

Huntsville, AL · Fullerton, CA · Los Angeles, CA · +19 more sites

RecruitingPhase 2NCT06887218

5-Fluorouracil/Leucovorin (5FU/LV) in Combination With Regorafenib in Patients With Metastatic Colorectal Cancer

Sponsor: The Methodist Hospital Research Institute

Houston, TX

RecruitingPhase 2NCT07446322

FOLFIRI and Bevacizumab With or Without Pelareorep for Second-Line Treatment of Metastatic RAS-Mutated, Microsatellite-Stable Colorectal Cancer

Sponsor: Oncolytics Biotech

Homewood, AL · Beverly Hills, CA · Encino, CA · +14 more sites

RecruitingPhase 2NCT05673148

Testing the Addition of Total Ablative Therapy to Usual Systemic Therapy Treatment for Limited Metastatic Colorectal Cancer, ERASur Trial

Sponsor: Alliance for Clinical Trials in Oncology

Kingman, AZ · Phoenix, AZ · Beverly Hills, CA · +185 more sites

RecruitingPhase 2NCT06265285

Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected Access and Remote Expertise) Beyond Walls (CCBW) Program

Sponsor: Mayo Clinic

Jacksonville, FL

RecruitingPhase 2NCT06760819

A Study to Learn More About How Well Treatment With Sevabertinib (BAY 2927088) Tablets Works and How Safe it is in Participants Who Have a Solid Tumor With Mutations of the Human Epidermal Growth Factor Receptor 2 (HER2)

Sponsor: Bayer

Birmingham, AL · Duarte, CA · Fort Myers, FL · +8 more sites

RecruitingPhase 2NCT07140679

Immunotherapy (Toripalimab) for Reducing Recurrence Risk After Surgery for Mismatch Repair Deficient Stage IIB, IIC, or III Colon Cancer

Sponsor: Emory University

Atlanta, GA · +2 more sites

RecruitingPhase 2NCT07285044

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

Sponsor: Mayo Clinic

Jacksonville, FL

RecruitingPhase 2NCT07551596

Testing the Combination of Anti-Cancer Drugs, Botensilimab (AGEN1181) and Balstilimab (AGEN2034), After Standard Treatment for Colorectal Cancer, Combat Trial

Sponsor: National Cancer Institute (NCI)

New Orleans, LA · Houston, TX

RecruitingPhase 2NCT06369259

Open-label Phase 2 Study of Avutometinib (RAF/MEK Clamp) in Combination With Defactinib (FAK Inhibitor) and Cetuximab in Patients With Unresectable, Anti-EGFR-Refractory Advanced Colorectal Cancer

Sponsor: M.D. Anderson Cancer Center

Houston, TX

RecruitingPhase 2NCT05489211

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

Sponsor: AstraZeneca

Los Angeles, CA · San Diego, CA · Santa Rosa, CA · +15 more sites

RecruitingPhase 2NCT07227636

A Study of Botensilimab and Balstilimab for Colorectal Cancer With ctDNA+ After Surgery and Chemotherapy

Sponsor: Memorial Sloan Kettering Cancer Center

Basking Ridge, NJ · Middletown, NJ · Montvale, NJ · +4 more sites

RecruitingPhase 2NCT05854498

Liposomal Irinotecan With TAS102 and Bevacizumab for Patients With Metastatic Colorectal Cancer

Sponsor: University of Wisconsin, Madison

Madison, WI

RecruitingPhase 2NCT04899908

Stereotactic Brain-directed Radiation With or Without Aguix Gadolinium-Based Nanoparticles in Brain Metastases

Sponsor: Brigham and Women's Hospital

Boston, MA

RecruitingPhase 2NCT07795749

Ph II Intraperitoneal Paclitaxel + System Therapy in GI Ca w/Peritoneal Carcinomatosis (STOPGAP-B)

Sponsor: University of California, Irvine

Orange, CA

RecruitingPhase 2NCT07071961

Regorafenib (Reg) and Lorigerlimab (Lor), RELO Regimen, in Treatment of High-risk Patients With Colorectal Cancer With Radiographic Occult Molecular Residual Disease After End of Established Definitive Therapy [ReLOAD Trial]

Sponsor: M.D. Anderson Cancer Center

Houston, TX

RecruitingPhase 2NCT06728072

Addition of Antibiotics to Upfront Treatment Regimen for Colorectal Cancer

Sponsor: Virginia Commonwealth University

Richmond, VA

RecruitingPhase 2NCT06792695

A Study of Novel Study Interventions and Combinations in Participants With Colorectal Cancer

Sponsor: AstraZeneca

Scottsdale, AZ · Los Angeles, CA · Washington D.C., DC · +11 more sites

RecruitingPhase 2NCT07425054

ctHPVDNA Response-Adapted Chemoradiation +/- Retifanlimab Treatment in Locally-Advanced Anal Cancer

Sponsor: Jennifer Dorth

Cleveland, OH

RecruitingPhase 2NCT07550088

BAL/BOT/agenT-797 in pMMR CRC With Liver Metastases

Sponsor: Darren Sigal, MD

La Jolla, CA

RecruitingPhase 2NCT07527858

Study of Denikitug (GS-1811) Given Alone or With Nivolumab or With Chemotherapy in Adults With Advanced Colorectal Cancer

Sponsor: Gilead Sciences

North Haven, CT · Boston, MA · +3 more sites

RecruitingPhase 2NCT05705492

Olanzapine for the Management of Cancer Associated Appetite Loss in Patients With Advanced Esophagogastric, Hepatopancreaticobiliary, Colorectal or Lung Cancer

Sponsor: OHSU Knight Cancer Institute

Portland, OR

RecruitingPhase 2NCT06948448

A Study to Evaluate the Safety and Efficacy of Two Dose Levels of ONO-4578 With Opdivo®, in Combination With mFOLFOX6 and Bevacizumab Versus Standard of Care in Participants With Non-MSI-H/dMMR, PD-L1 Positive Advanced Colorectal Cancer

Sponsor: Ono Pharmaceutical Co., Ltd.

Phoenix, AZ · Los Angeles, CA · Lone Tree, CO · +8 more sites

RecruitingPhase 2NCT06937177

Safely Optimizing Body Weight With Mifomelatide (TCMCB07) in Patients With Newly Diagnosed Colorectal Cancer (CRC) or Pancreatic Ductal Adenocarcinoma (PDAC) Undergoing Chemotherapy

Sponsor: Endevica Bio

Tucson, AZ · Los Angeles, CA · Santa Monica, CA · +22 more sites

RecruitingPhase 2NCT06695845

A Phase 2 Study of Zanidatamab in Patients With HER2-expressing Tumors

Sponsor: Jazz Pharmaceuticals

Prescott, AZ · Littleton, CO · Fort Myers, FL · +14 more sites

RecruitingPhase 2NCT06959550

Phase II Study of Anti-PD-1/VEGF Bispecific Antibody Ivonescimab in Patients With Previously Treated Metastatic Colorectal Cancer

Sponsor: M.D. Anderson Cancer Center

Houston, TX

RecruitingPhase 2NCT06300463

Platform Study of Immunotherapy Combinations in Colorectal Cancer Liver Metastases

Sponsor: Weill Medical College of Cornell University

New York, NY

RecruitingPhase 2NCT05672524

A Study of Tucatinib and Trastuzumab in People With Rectal Cancer

Sponsor: Memorial Sloan Kettering Cancer Center

Basking Ridge, NJ · Middletown, NJ · Montvale, NJ · +4 more sites

RecruitingPhase 2NCT06205836

Cemiplimab With or Without Fianlimab to Treat Older Patients With Localized or Locally Advanced MSI-H Colorectal Cancer

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, MD

RecruitingPhase 2NCT07407647

Vaginal DHEA to Improve Vaginal Health After Radiation for Women With Gynecologic, Anal or Rectal Cancer

Sponsor: Ohio State University Comprehensive Cancer Center

Columbus, OH

RecruitingPhase 2NCT07405476

Zanidatamab Before Surgery for the Treatment of HER2 Positive Colon and Rectal Cancer in Patients Planned for Curative Intent Treatment

Sponsor: Emory University

Atlanta, GA · +1 more sites

RecruitingPhase 2NCT04701476

TATE and Pembrolizumab (MK3475) in mCRC and NSCLC

Sponsor: Teclison Ltd.

Orange, CA

RecruitingPhase 2NCT07223424

Patient Preference for Subcutaneous vs. Intravenous Immune Therapy

Sponsor: Diwakar Davar

Pittsburgh, PA

RecruitingPhase 2NCT04779554

Flat Dose vs. Weight-based IP Chemotherapy for CRS/HIPEC

Sponsor: Prakash Pandalai

Lexington, KY · Burlington, VT

RecruitingPhase 2NCT07033026

An Evaluation of NGM120 in a Randomized, Double-blind, Placebo-controlled Study in Participants With Colorectal Cancer Who Have Cancer Cachexia.

Sponsor: NGM Biopharmaceuticals, Inc

Los Angeles, CA · Santa Rosa, CA · +10 more sites

RecruitingPhase 2NCT05806931

Sequential TAS-OX Alternating With TAS-IRI Plus Bevacizumab for Late-Line Metastatic Colorectal Cancer

Sponsor: Rutgers, The State University of New Jersey

Elizabeth, NJ · Jersey City, NJ · Lakewood, NJ · +6 more sites

RecruitingPhase 2NCT05672108

Phase II Trial of Lung Chemoemobolization

Sponsor: City of Hope Medical Center

Duarte, CA · New York, NY

RecruitingPhase 2NCT07447050

Riluzole For Preventing Cognitive Dysfunction in Ca Pts Receiving Chemo (REFOCUS): Pilot Trial

Sponsor: University of California, Irvine

Orange, CA

RecruitingPhase 2NCT07433673

Gemcitabine, Cisplatin, Nab-paclitaxel (GAP) and Cemiplimab for Locally Advanced Biliary Tract Cancer (BTC)

Sponsor: Columbia University

New York, NY

RecruitingPhase 2NCT06130280

A Study of Single Fraction Stereotactic Body Radiation Therapy (SBRT) Guided by Magnetic Resonance Imaging (MRI) in People With Liver Metastasis From Colorectal Cancer

Sponsor: Memorial Sloan Kettering Cancer Center

Basking Ridge, NJ · Middletown, NJ · Montvale, NJ · +4 more sites

RecruitingPhase 2NCT07201519

Study of Safety/Feasibility of a Hybrid Model of Tertiary and Community Delivery of Hepatic Artery Infusion Chemotherapy

Sponsor: Michael J Cavnar, MD

Lexington, KY

RecruitingPhase 2NCT06731894

Phytocannabinoids for Reducing Chronic Chemotherapy-Induced Peripheral Neuropathy in Breast and Colon Cancer Survivors

Sponsor: City of Hope Medical Center

Duarte, CA · Irvine, CA

RecruitingPhase 2NCT03175224

APL-101 Study of Subjects With NSCLC With c-Met EXON 14 Skip Mutations and c-Met Dysregulation Advanced Solid Tumors

Sponsor: Apollomics Inc.

Los Angeles, CA · Tampa, FL · Boston, MA · +3 more sites

RecruitingPhase 2NCT06612281

Evaluation of Gixam's Performance in a FIT Negative Population

Sponsor: Jubaan Ltd.

Portland, OR

Not yet recruitingPhase 2NCT07612007

HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization

Sponsor: Mayo Clinic

Rochester, MN

Not yet recruitingPhase 2NCT07796763

A Global Trial of Trastuzumab Rezetecan (SHR-A1811) in Combination With Chemotherapy and Bevacizumab as First-Line Treatment in Patients With Advanced Colorectal Cancer Expressing HER2

Sponsor: Jiangsu HengRui Medicine Co., Ltd.

Houston, TX

Not yet recruitingPhase 2NCT07209215

ctDNA-Informed Management of Early-Stage Rectal Cancer

Sponsor: University of California, Davis

Sacramento, CA

Not yet recruitingPhase 2NCT07580339

Combining DCSZ11 With Radiation and Chemotherapy as Neoadjuvant Treatment for pMMR Locally Advanced Rectal Cancer

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Baltimore, MD

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.