RecruitingPhase 2NCT07752979
Safety and Efficacy of ABBV-295 in Adults With Obesity or Overweight With Weight-Related Comorbidities
Sponsor: AbbVie
Bristol, TN · Knoxville, TN · +56 more sites
Clinical trials in Knoxville, TN
73 recruiting studies have a site in or near Knoxville, TN, Tennessee.
Top conditions here
- Lung Cancer (13)
- Obesity (10)
- Hypertension (8)
- Leukemia (8)
- Breast Cancer (7)
- Multiple Sclerosis (7)
- COPD (6)
- Heart Failure (5)
All conditions
- Alzheimer's Disease
- Asthma
- Breast Cancer
- COPD
- Crohn's Disease
- Depression
- Type 1 Diabetes
- Type 2 Diabetes
- Heart Failure
- Hypertension
- Leukemia
- Lung Cancer
- Lupus
- Migraine
- Multiple Sclerosis
- Obesity
- Parkinson's Disease
- Prostate Cancer
- Psoriasis
- Rheumatoid Arthritis
- Schizophrenia
- Sickle Cell Disease
- Ulcerative Colitis
- Colorectal Cancer
Showing 40 of 73 studies
RecruitingPhase 3NCT04267848
Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small Cell Lung Cancer, an ALCHEMIST Treatment Trial (Chemo-IO [ACCIO])
Sponsor: National Cancer Institute (NCI)
Alcoa, TN · Bristol, TN · Collierville, TN · +1147 more sites
RecruitingPhase 2NCT06317662
Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia
Sponsor: National Cancer Institute (NCI)
Knoxville, TN · Memphis, TN · Nashville, TN · +112 more sites
RecruitingPhase 4NCT07133880
Compare the Effects of Nebulizer Versus Inhaler Based Therapy for COPD Using Long-acting Bronchodilators
Sponsor: University of Tennessee Graduate School of Medicine
Knoxville, TN
RecruitingPhase 3NCT07513376
A Clinical Trial of Adjuvant Intismeran (V940) With or Without Pembrolizumab Coformulated With Berahyaluronidase Alfa (MK-3475A) in High-Risk Stage I Non-Small Cell Lung Cancer (V940-014)
Sponsor: Merck Sharp & Dohme LLC
Knoxville, TN · +23 more sites
RecruitingPhase 2NCT05554393
Comparing Cytarabine + Daunorubicin Therapy Versus Cytarabine + Daunorubicin + Venetoclax Versus Venetoclax + Azacitidine in Younger Patients With Intermediate Risk AML (A MyeloMATCH Treatment Trial)
Sponsor: National Cancer Institute (NCI)
Collierville, TN · Knoxville, TN · Memphis, TN · +172 more sites
RecruitingPhase 3NCT06623422
A Study of Pembrolizumab (MK-3475) With or Without Intismeran Autogene (V940) in Participants With Non-small Cell Lung Cancer (V940-009/INTerpath-009)
Sponsor: Merck Sharp & Dohme LLC
Chattanooga, TN · Knoxville, TN · Memphis, TN · +51 more sites
RecruitingPhase 2 / Phase 3NCT06712316
Safety, Efficacy, and Pharmacokinetics of BNT327 in Combination With Chemotherapy and Other Investigational Agents for Lung Cancer (ROSETTA Lung-02)
Sponsor: BioNTech SE
Knoxville, TN · Memphis, TN · Nashville, TN · +50 more sites
RecruitingPhase 3NCT07177352
Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies
Sponsor: Hoffmann-La Roche
Knoxville, TN · Nashville, TN · +66 more sites
RecruitingPhase 3NCT07181109
Zilebesiran in Patients With Hypertension Not Adequately Controlled and With Either Established Cardiovascular Disease or High Risk for Cardiovascular Disease
Sponsor: Alnylam Pharmaceuticals
Chattanooga, TN · Knoxville, TN · +270 more sites
RecruitingPhase 2NCT07697456
Study of Advanced Therapies for the Treatment of Adult Participants With Moderately to Severely Active Crohn's Disease or Ulcerative Colitis
Sponsor: AbbVie
Knoxville, TN · Memphis, TN · +58 more sites
RecruitingPhase 2NCT06317649
Venetoclax and HMA Treatment of Older and Unfit Adults With FLT3 Mutated Acute Myeloid Leukemia (AML) (A MyeloMATCH Treatment Trial)
Sponsor: National Cancer Institute (NCI)
Collierville, TN · Knoxville, TN · Memphis, TN · +222 more sites
RecruitingPhase 3NCT06712355
Safety and Efficacy of BNT327, an Investigational Therapy in Combination With Chemotherapy for Patients With Untreated Small-cell Lung Cancer
Sponsor: BioNTech SE
Germantown, TN · Knoxville, TN · +34 more sites
RecruitingPhase 3NCT07064473
EASi-PROTKT™ - A Study to Test Vicadrostat (BI 690517) Taken Together With Empagliflozin in People With Type 2 Diabetes, High Blood Pressure, and Cardiovascular Disease
Sponsor: Boehringer Ingelheim
Knoxville, TN · +207 more sites
RecruitingPhase 3NCT06307652
Study to Evaluate the Effect of Balcinrenone/Dapagliflozin in Patients With Heart Failure and Impaired Kidney Function
Sponsor: AstraZeneca
Jackson, TN · Knoxville, TN · Memphis, TN · +163 more sites
RecruitingPhase 2NCT06672146
Comparing New Treatments for People With Newly Diagnosed Acute Myeloid Leukemia That Has an IDH2 Gene Change (A MyeloMATCH Treatment Trial)
Sponsor: National Cancer Institute (NCI)
Knoxville, TN · +134 more sites
RecruitingPhase 3NCT06736574
Study With Omecamtiv Mecarbil (CK-1827452) to Treat Chronic Heart Failure With Severely Reduced Ejection Fraction
Sponsor: Cytokinetics
Germantown, TN · Knoxville, TN · Nashville, TN · +85 more sites
RecruitingPhase 3NCT06966700
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
Sponsor: Merck Sharp & Dohme LLC
Knoxville, TN · Nashville, TN · +61 more sites
RecruitingPhase 3NCT07144280
A Study to Learn About the Study Medicine Called PF-08046054/SGN-PDL1V Versus Docetaxel in Adult Participants With Previously-Treated Programmed Cell Death Ligand 1 (PD-L1) Positive Non-Small-Cell Lung Cancer (NSCLC)
Sponsor: Pfizer
Bartlett, TN · Chattanooga, TN · +238 more sites
RecruitingPhase 3NCT07216703
A Clinical Study of Sacituzumab Tirumotecan (MK-2870) in Combination With Pembrolizumab (MK-3475) as First-line Maintenance Treatment of Cervical Cancer (MK-2870-036/TroFuse-036/GOG-3123/ENGOT-cx22)
Sponsor: Merck Sharp & Dohme LLC
Knoxville, TN · +29 more sites
RecruitingPhase 3NCT07325292
Non-inferiority Study of Frexalimab Subcutaneous Administration Compared to Intravenous Administration in Adult Participants With Multiple Sclerosis
Sponsor: Sanofi
Knoxville, TN · +33 more sites
RecruitingPhase 3NCT07667803
A Master Protocol to Investigate Efficacy and Safety of Elecoglipron in Participants With Obesity or Overweight With or Without T2DM
Sponsor: AstraZeneca
Franklin, TN · Knoxville, TN · +54 more sites
RecruitingPhase 3NCT06878261
A Study to Investigate the Efficacy and Safety of Tezepelumab in Adult Participants With Moderate to Very Severe COPD (D5241C00007)
Sponsor: AstraZeneca
Hendersonville, TN · Knoxville, TN · Lebanon, TN · +77 more sites
RecruitingNot applicableNCT06911632
Multi-site Study of the Clinical Impact of an AI-assisted Approach to Referring Patients With Interstitial Lung Disease for Diagnostic Evaluation of Pulmonary Hypertension
Sponsor: Tempus AI
Knoxville, TN · +39 more sites
RecruitingPhase 3NCT07037433
Evaluating the Impact of Maridebart Cafraglutide on Cardiovascular Outcomes in Participants With Atherosclerotic Cardiovascular Disease and Overweight or Obesity
Sponsor: Amgen
Germantown, TN · Knoxville, TN · Powell, TN · +137 more sites
RecruitingPhase 3NCT07222566
Symbiotic-Lung-01 : A Study to Learn About the Study Medicine Called PF-08634404 in Combination With Chemotherapy in Adult Participants With Locally Advanced or Metastatic Non-Small Cell Lung Cancer
Sponsor: Pfizer
Chattanooga, TN · Franklin, TN · +223 more sites
RecruitingPhase 3NCT07794579
A Study of Orforglipron in Participants With Overweight at Risk of Development of Obesity-Related Complications or Progression to Class 1 Obesity
Sponsor: Eli Lilly and Company
Knoxville, TN · Nashville, TN · +78 more sites
RecruitingPhase 3NCT06119581
A Study of First-Line Olomorasib (LY3537982) and Pembrolizumab With or Without Chemotherapy in Patients With Advanced KRAS G12C-Mutant Non-small Cell Lung Cancer
Sponsor: Eli Lilly and Company
Chattanooga, TN · Knoxville, TN · Memphis, TN · +84 more sites
RecruitingNot applicableNCT06812533
Alleviant ALLAY-HFrEF Study
Sponsor: Alleviant Medical, Inc.
Knoxville, TN · +39 more sites
RecruitingPhase 3NCT06961214
Depemokimab as an Extended Treatment Duration Biologic in Adults With Chronic Obstructive Pulmonary Disease (COPD) and Type 2 Inflammation (ENDURA-2)
Sponsor: GlaxoSmithKline
Knoxville, TN · +56 more sites
RecruitingPhase 3NCT06982521
Phase 3 Study of RLY-2608 + Fulvestrant vs Capivasertib + Fulvestrant as Treatment for Locally Advanced or Metastatic PIK3CA-mutant HR+/HER2- Breast Cancer
Sponsor: Relay Therapeutics, Inc.
Knoxville, TN · Nashville, TN · +50 more sites
RecruitingPhase 2 / Phase 3NCT07155187
A Study to Assess Adverse Events and Change in Disease Activity of Intravenous (IV) Telisotuzumab Adizutecan, Monotherapy or in Combination With Osimertinib, Compared to Standard of Care in Adult Participants With Locally Advanced or Metastatic EGFR-Mutated Non-Squamous Non-Small Cell Lung Cancer
Sponsor: AbbVie
Knoxville, TN · Nashville, TN · +14 more sites
RecruitingPhase 3NCT07684235
Extension Trial to Evaluate the Long-term Efficacy, Safety, and Tolerability of Maridebart Cafraglutide (MARITIME-1-EXTENSION)
Sponsor: Amgen
Knoxville, TN · +69 more sites
RecruitingPhase 2NCT06782490
A Study to Evaluate the Efficacy, Safety and Tolerability of BMS-986368 in Participants With Multiple Sclerosis Spasticity
Sponsor: Celgene
Knoxville, TN · +15 more sites
RecruitingPhase 3NCT06742723
A Phase III Renal Outcomes and Cardiovascular Mortality Study to Investigate the Efficacy and Safety of Baxdrostat in Combination With Dapagliflozin in Participants With Chronic Kidney Disease and High Blood Pressure
Sponsor: AstraZeneca
Chattanooga, TN · Knoxville, TN · +130 more sites
RecruitingPhase 3NCT06852222
A Study of Bleximenib, Venetoclax and Azacitidine For Treatment of Participants With Newly Diagnosed Acute Myeloid Leukemia (AML)
Sponsor: Janssen Research & Development, LLC
Knoxville, TN · Nashville, TN · +57 more sites
RecruitingPhase 2NCT06932263
Dose Range Finding Study to Assess Efficacy and Safety of Tozorakimab in Adults With Uncontrolled Asthma on Medium-to-High Dose Inhaled Corticosteroids
Sponsor: AstraZeneca
Knoxville, TN · +63 more sites
RecruitingPhase 3NCT07225946
A Study of Pasritamig With Docetaxel Versus Docetaxel in Participants With Metastatic Castration-Resistant Prostate Cancer
Sponsor: Janssen Research & Development, LLC
Knoxville, TN · +58 more sites
RecruitingPhase 3NCT06357533
Phase III, Open-label, Study of First-line Dato-DXd in Combination With Rilvegostomig for Advanced Non-squamous NSCLC With High PD-L1 Expression (TC ≥ 50%) and Without Actionable Genomic Alterations
Sponsor: AstraZeneca
Chattanooga, TN · Knoxville, TN · +61 more sites
RecruitingPhase not listedNCT06433752
A Study Evaluating the Real World Experience of Participants Treated With BRIUMVI® (Ublituximab-xiiy) for Relapsing Multiple Sclerosis (RMS)
Sponsor: TG Therapeutics, Inc.
Franklin, TN · Knoxville, TN · Mount Juliet, TN · +106 more sites
Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.