Lupus clinical trials

99 recruiting studies in the US for lupus, an autoimmune disease that can affect many parts of the body.

Lupus trials include a notable share of early-phase studies, including Phase 1 work on cell-based therapies, alongside Phase 2 and 3 trials of targeted medicines. Many studies focus on specific features such as lupus nephritis (kidney involvement) or skin disease. Expect questions about current steroid dose and recent disease activity.

Top locations

By phase

Showing 40 of 99 studies

RecruitingPhase not listedNCT06948110

Deciphering the Genetic Architecture of Autoimmune Diseases

Sponsor: National Human Genome Research Institute (NHGRI)

Bethesda, MD

RecruitingPhase 1NCT07607964

A Study to Assess Adverse Events, How the Drug Moves Through the Body and Effectiveness of Intravenous Infusions and Subcutaneous Injections of ABBV-519 in Adult Participants With Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis (RA)

Sponsor: AbbVie

Anniston, AL · Tustin, CA · Clearwater, FL · +9 more sites

RecruitingPhase 1NCT06916806

A Study to Investigate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AZD5492 in Adult Participants With Systemic Lupus Erythematosus or Idiopathic Inflammatory Myopathies or Rheumatoid Arthritis.

Sponsor: AstraZeneca

Anniston, AL · Birmingham, AL · La Jolla, CA · +4 more sites

RecruitingNot applicableNCT07783152

Lupus Nephritis Care Pathway

Sponsor: Duke University

Durham, NC

RecruitingPhase 3NCT06617325

A Study to Evaluate the Efficacy and Safety of Dapirolizumab Pegol in Study Participants With Moderately to Severely Active Systemic Lupus Erythematosus

Sponsor: UCB Biopharma SRL

Avondale, AZ · Chandler, AZ · Gilbert, AZ · +60 more sites

RecruitingPhase 2NCT07409181

A Study to Test Whether Different Doses of BI 3000202 Help People With Systemic Lupus Erythematosus (SLE)

Sponsor: Boehringer Ingelheim

Beverly Hills, CA · La Palma, CA · San Diego, CA · +27 more sites

RecruitingPhase 3NCT06133972

Phase 3 Extension Study to Evaluate Long-term Safety of Ianalumab in Participants With Systemic Lupus Erythematosus (SIRIUS-SLE Extension).

Sponsor: Novartis Pharmaceuticals

Anniston, AL · Burbank, CA · La Palma, CA · +22 more sites

RecruitingPhase 3NCT06711887

Phase III Extension Study of Efficacy and Safety of Ianalumab With or Without Study Treatment Withdrawal in Participants With Lupus Nephritis (SIRIUS-LN Extension)

Sponsor: Novartis Pharmaceuticals

Orchard Park, NY

RecruitingPhase not listedNCT00001372

Study of Systemic Lupus Erythematosus

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Bethesda, MD

RecruitingPhase 2NCT05039619

A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Obinutuzumab in Adolescents With Active Class III or IV Lupus Nephritis and the Safety and PK of Obinutuzumab in Pediatric Participants

Sponsor: Hoffmann-La Roche

Loma Linda, CA · San Francisco, CA · Aurora, CO · +8 more sites

RecruitingPhase 1 / Phase 2NCT06121297

RESET-SLE: A Phase 1/2 Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Systemic Lupus Erythematosus

Sponsor: Cabaletta Bio

Orange, CA · Sacramento, CA · New Haven, CT · +18 more sites

RecruitingPhase 1 / Phase 2NCT06434363

Phase I/II Study of AD-PluReceptor Plus Tafasitamab-cxix and Lymphodepleting Chemotherapy in Patients With Autoimmune Disorders

Sponsor: M.D. Anderson Cancer Center

Houston, TX

RecruitingPhase 3NCT07332481

A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease

Sponsor: EMD Serono Research & Development Institute, Inc.

Los Angeles, CA · Thousand Oaks, CA · Cooper City, FL · +9 more sites

RecruitingPhase 3NCT07355218

A Study of Enpatoran in Participants With Cutaneous Manifestations of Lupus With or Without Systemic Disease (ELOWEN-2)

Sponsor: EMD Serono Research & Development Institute, Inc.

Upland, CA · DeBary, FL · Fort Lauderdale, FL · +11 more sites

RecruitingPhase 1NCT03816345

Testing an Immunotherapy Anti-cancer Drug, Nivolumab, for Advanced Cancers in Patients With Autoimmune Disorders, AIM-NIVO

Sponsor: National Cancer Institute (NCI)

Birmingham, AL · Palo Alto, CA · Sacramento, CA · +48 more sites

RecruitingPhase 2NCT06570798

A Phase 2 Master Protocol Assessing Inebilizumab and Blinatumomab in Autoimmune Diseases

Sponsor: Amgen

Scottsdale, AZ · Aurora, CO · Hialeah, FL · +15 more sites

RecruitingPhase 2NCT07260877

A Multicenter, Randomized, Double-Blind, Placebo-Controlled, Phase 2a Study With an Open-Label Extension Evaluating the Efficacy and Safety of VENT-03 in Adult Participants With Active Cutaneous Lupus Erythematosus With or Without Systemic Lupus Erythematosus

Sponsor: Ventus Therapeutics U.S., Inc.

Beverly Hills, CA · Clearwater, FL · DeBary, FL · +12 more sites

RecruitingPhase 3NCT07691970

Rollover Study for Participants Who Have Completed a Previous Clinical Study With Anifrolumab (Saphnelo) and Clinically Benefited From Continued Treatment

Sponsor: AstraZeneca

Phoenix, AZ · Los Angeles, CA · San Francisco, CA · +12 more sites

RecruitingPhase 2NCT06419205

A Phase 2 Study to Evaluate the Safety, PD, PK, and Clinical Activity of ADX-097 in Participants With IgAN, LN or C3G

Sponsor: Akebia Therapeutics

Hollywood, FL · Lawrenceville, GA · Orangeburg, SC

RecruitingPhase 3NCT05835310

An Efficacy and Safety Study of Intravenous Anifrolumab to Treat Systemic Lupus Erythematosus in Pediatric Participants

Sponsor: AstraZeneca

Phoenix, AZ · Los Angeles, CA · Washington D.C., DC · +19 more sites

RecruitingPhase not listedNCT05567198

Gonadotropin-releasing Hormone Agonist (GnRHa) in Ovarian Preservation in SLE Subjects Receiving Cyclophosphamide as Determined by Questionnaires

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Bethesda, MD

RecruitingPhase 3NCT07430306

A Study to Evaluate the Treatment Outcomes of Subcutaneous Anifrolumab in Immunosuppressant-naïve and Biologic-naïve Systemic Lupus Erythematosus

Sponsor: AstraZeneca

Anniston, AL · Birmingham, AL · Phoenix, AZ · +28 more sites

RecruitingPhase 3NCT07438496

A Study of Nipocalimab in Adults With Moderate to Severe Systemic Lupus Erythematosus

Sponsor: Janssen Research & Development, LLC

Beverly Hills, CA · Fullerton, CA · Hemet, CA · +35 more sites

RecruitingPhase 1 / Phase 2NCT06839976

CD19-Directed Chimeric Antigen Receptor Autologous T Cells (CART19) for Lupus

Sponsor: Children's Hospital of Philadelphia

Philadelphia, PA

RecruitingPhase 2NCT05440422

The Role of Anifrolumab in Improving Markers of Vascular Risk in Patients With Systemic Lupus Erythematosus (SLE) - IFN-CVD

Sponsor: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)

Bethesda, MD

RecruitingPhase not listedNCT07049653

Anifrolumab Pregnancy Study

Sponsor: AstraZeneca

Cary, NC

RecruitingPhase 1NCT07201558

Study Evaluating Safety, Tolerability, PK/PD of Surovatamig in Adult RA or SLE Participants

Sponsor: AstraZeneca

Birmingham, AL · Fullerton, CA · Plantation, FL · +3 more sites

RecruitingPhase 2NCT06987565

Transcutaneous Vagus Nerve Stimulation in SLE

Sponsor: Northwell Health

Manhasset, NY

RecruitingPhase 2NCT07328581

A Phase IIa Study of ICG318 CAR-T in Refractory Systemic Lupus Erythematosus With or Without Lupus Nephritis

Sponsor: iCell Gene Therapeutics

Chicago, IL · Hawthorne, NY · New Hyde Park, NY · +1 more sites

RecruitingPhase 2NCT05201469

VIBRANT: VIB4920 for Active Lupus Nephritis

Sponsor: National Institute of Allergy and Infectious Diseases (NIAID)

La Jolla, CA · Los Angeles, CA · Orange, CA · +14 more sites

RecruitingPhase 4NCT06594068

Prospective Registry Investigating Maternal, Infant, and Lactation Outcomes in Anifrolumab Users

Sponsor: AstraZeneca

Las Vegas, NV

RecruitingNot applicableNCT07823478

HEALTH Home Urinalysis Testing

Sponsor: NYU Langone Health

New York, NY

RecruitingPhase 2NCT05538208

The Pediatric Lupus Nephritis Mycophenolate Mofetil (PLUMM) Study

Sponsor: Children's Hospital Medical Center, Cincinnati

San Francisco, CA · Aurora, CO · Atlanta, GA · +16 more sites

RecruitingPhase 1NCT06975787

Dose Escalation Study With Bispecific Antibodies in Adult Participants With Lupus Nephritis

Sponsor: Regeneron Pharmaceuticals

San Francisco, CA · Rochester, MN · Houston, TX

RecruitingPhase 2NCT07570862

A Phase 2, Open-Label, Single-Arm Trial of FT819 in Participants With Lupus Nephritis

Sponsor: Fate Therapeutics

Beverly Hills, CA · Fontana, CA · Fullerton, CA · +9 more sites

RecruitingPhase 1 / Phase 2NCT06897930

A Study to Investigate the Safety, Tolerability, and Efficacy of AZD0120 in Adults With Refractory SLE

Sponsor: AstraZeneca

San Francisco, CA · Stanford, CA · Tampa, FL · +13 more sites

RecruitingPhase 1NCT07085104

A Study to Investigate the Safety and Preliminary Efficacy of ALLO-329, an Allogeneic CAR T-cell Therapy, in Adults With Autoimmune Disease

Sponsor: Allogene Therapeutics

Phoenix, AZ · Loma Linda, CA · Aurora, CO · +13 more sites

RecruitingPhase 4NCT06875960

A Study to Continue the Administration of Deucravacitinib in Participants With Systemic Lupus Erythematosus (SLE) or Discoid and/or Subacute Cutaneous Lupus Erythematosus (DLE/SCLE) Who Have Completed Study IM011074 or Study IM011132

Sponsor: Bristol-Myers Squibb

Farmington, CT · New York, NY · Oklahoma City, OK · +1 more sites

RecruitingPhase not listedNCT07175285

A Study in Participants With Active Systemic Lupus Erythematosus With Inadequate Response to Glucocorticoids and ≥2 Immunosuppressants

Sponsor: Bristol-Myers Squibb

La Jolla, CA · La Palma, CA · Los Angeles, CA · +23 more sites

RecruitingPhase not listedNCT06659029

Prospective Registry Investigating Maternal and Infant Outcomes in Anifrolumab Users

Sponsor: AstraZeneca

Wilmington, NC

Related conditions

Listings come from ClinicalTrials.gov and are provided for information only. Always confirm eligibility with the study team and talk with your doctor before making decisions about your care.