RightFit
RecruitingPhase 1 / Phase 2

RH Genotype Matched RBC Transfusions

RH Genotype Matched Red Cell Transfusions for Patients With Sickle Cell Disease

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
6 Months and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Time periods mentioned: 3 years

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "Patients will receive RH matched red cells for the duration of their chronic transfusion therapy or up to three years, whichever is shorter."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether matching donated red blood cells by RH genes is possible and works well. RH genes affect markers on red blood cells. It is for people with sickle cell disease who need regular red blood cell transfusions.

To determine the feasibility and efficacy of matching donor red cells by RH genotype for a cohort of chronically transfused patients with SCD.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Older than 6 months.
  • Have any type of sickle cell disease.
  • Need regular red blood cell transfusions for a period of time.
  • You, your parent, or your guardian must give informed permission. Children must also agree when appropriate.

Who can't join

  • Have a rare RH gene type that makes it too hard to find enough matching blood.
  • Have immune proteins called antibodies against blood cell markers that make it too hard to find enough suitable blood.
  • Have antibodies against the D marker on red blood cells.
  • Have antibodies against Rh markers, and RH gene-matched blood would expose you to a marker not allowed under usual care and blood bank rules.
  • The study doctor thinks you, your parents, or your guardians may not follow the study schedule or steps.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Subjects age \>6 months * Diagnosis of SCD, all genotypes * Require a period of chronic red cell transfusion therapy * Subject/parental/guardian permission (informed consent) and if appropriate, child assent Exclusion Criteria: * Rare RH genotype that would preclude identification of sufficient RBC units * Antigen negative requirements due to alloimmunization that would preclude identification of sufficient RBC units * Alloimmunized to D antigen * Rh alloimmunized patients for whom providing RH genotype matched blood would expose the patient to an antigen that would not be consistent with standard of care and blood bank protocols * Parents/guardians or subjects who, in the opinion of the Investigator, may be non-compliant with study schedules or procedures

Study sites (1)

PA