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Metabolic Inflexibility is Related to Elevated Muscle Anaerobic Glycolysis

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 50 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

The focus of this proposal is on overweight (25\>BMI\<30 kg/m2) subjects, as these individuals exhibit a high risk of becoming obese and/or developing metabolic diseases. We hypothesize that in some overweight individuals there is a "metabolic program" in skeletal muscle which predisposes them to the development of obesity. Findings may lead to clinical screening tools for determining risk for obesity in non-obese individuals and targeting this group for prevention.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Official eligibility criteria

Inclusion Criteria: * 18-50 years old * BMI of 25 - 30 kg/m2 * BMI \> 40kg/m2 * Lactate levels in top and lower 25% Exclusion Criteria: * Pregnant women * Mentally disabled * Prisoners * Smokers * Subjects with heart disease * Type 1 and 2 diabetes * Endocrine disease * Hypertension * Musculoskeletal disease * Peripheral occlusion * Hepatic disease * Have had weight fluctuations exceeding + 3% in the previous 12 months * On medications which alter carbohydrate metabolism will not be studied

Study sites (1)

NC