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The Utility and Feasibility of Mt-sDNA as a Surveillance Procedure in Colorectal Cancer Survivors

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years and older
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study tests whether a stool test that looks for several markers can find polyps (growths) and cancer compared with standard tests. It is for people who had stage I, II, or III colon or rectal cancer and surgery to remove part of their bowel.

The purpose of this research study is to determine whether testing of stool for a panel of markers will enable us to detect polyps and cancer compared to standard testing.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Were diagnosed with stage I, II, or III adenocarcinoma, a type of cancer in the colon or rectum.
  • Had a colonoscopy before surgery—a test that uses a camera to look inside the bowel.
  • Had surgery to remove part of the bowel, with chemotherapy or radiation afterward if needed.

Who can't join

  • Have stage IV colon or rectal cancer.
  • Had surgery to remove most of the colon, or all of the colon and rectum.
  • Have inflammatory bowel disease, such as ulcerative colitis or Crohn’s disease.
  • Have a condition linked to bowel polyps or cancer, including Lynch syndrome or familial polyposis.
  • Have high-risk polyps that were not removed during the colonoscopy or surgery. These include polyps at least 1 cm wide or with certain shapes or very abnormal cells.
  • Cannot give informed consent, meaning you cannot understand and agree to take part.
  • Cannot understand spoken and written English.
  • Have other health problems that make sedation (medicine to relax you) unsafe or mean routine follow-up checks after surgery would not help, as judged by your care providers.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * Diagnosis of stage I, II or III adenocarcinoma of the colon or rectum * Receipt of preoperative colonoscopy * Receipt of bowel resection; use of adjuvant chemotherapy or radiation therapy as clinically indicated Exclusion Criteria: * Stage IV colorectal cancer * Surgical treatment with subtotal colectomy or total proctocolectomy * Diagnosis of inflammatory bowel disease (ulcerative colitis or Crohn's disease) * Diagnosis of polyposis syndrome including Lynch syndrome or familial polyposis * Presence of advanced adenomas (1 cm or larger, villous features and/or high grade dysplasia) that were not removed at the preoperative colonoscopy or contained in the resection specimen. * Inability to provide informed consent * Inability to understand spoken and written English * Medical comorbidities that would be contraindications to sedation or that would preclude any benefit of routine surveillance post-resection. These would be at the discretion of the participant's providers.

Study sites (1)

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