RightFit
RecruitingEarly Phase 1

Sex Disparities in Hypoxic Vasodilation and Impact of Obesity

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 45 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how blood vessels widen when oxygen is low, and how this differs by sex. It also looks at how obesity and the nerves that control the body's stress response affect this process. People with a body mass index (BMI) above 18 may qualify.

The purpose of this project is to examine key mechanisms contributing to sex-differences in hypoxic vasodilation and the impact of obesity, with particular emphasis on the sympathetic nervous system.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • BMI above 18. BMI is a measure based on height and weight.

Who can't join

  • Pregnant or breastfeeding.
  • Diagnosed sleep apnea, or more than 10 pauses or drops in breathing per hour during sleep.
  • Current smoking or nicotine use.
  • Higher risk of bleeding, a disorder that affects blood clotting, or use of blood thinners.
  • Nerve disease, or disease of the heart, blood vessels, liver, kidneys, or lungs.
  • Blood pressure of 140/90 or higher.
  • Diabetes or polycystic ovarian syndrome, a condition that affects hormones and the ovaries.
  • Barriers to communication, use of prescription medicines, or sensitivity to lidocaine, a numbing medicine.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * BMI \>18 kg/m2 Exclusion Criteria: * Pregnancy, breastfeeding * Diagnosed sleep apnea or AHI \>10 events/hr * Current smoking/Nicotine use * Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy * Nerve/neurologic disease * Cardiovascular, hepatic, renal, respiratory disease * Blood pressure ≥140/90 mmHg * Diabetes, Polycystic ovarian syndrome * Communication barriers * Prescription medications, Sensitivity to lidocaine

Study sites (1)

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