His-Bundle Corrective Pacing in Heart Failure
Who can join
As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.
- Age
- 18 Years and older
- Sex
- All sexes
- Healthy volunteers
- Not accepted
- Compensation
- Not stated
Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.
What to expect
No one can promise a trial will help you personally — that is what the research is trying to find out.
What participation involves
- Procedures mentioned: Heart tracing (ECG)
Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.
Show the study's own words
- "BIV-CRT arm at 6 months, and by evaluating changes in ECG biomarkers, NT-pro-brain natriuretic peptide (NT-proBNP) levels, and echocardiography biomarkers (left ventricular volumes, strain contractility, and dyssynchrony), as well as temporal changes in functional status and quality of life in the His-CRT vs."
- Compensation
- Not stated
- Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
- Participants are monitored closely by the research team throughout the study.
- Some participants may receive access to an investigational treatment, which is still being studied.
- Your participation helps researchers learn whether this approach could help future patients.
About this study
The investigators aim to prospectively evaluate the efficacy and mechanism of benefit of His-bundle pacing enhanced cardiac resynchronization therapy (His-CRT) vs. cardiac resynchronization therapy (BIV-CRT) in patients with heart failure and right bundle branch block (RBBB).
Compensation is read from the study's own description and may be missing — always confirm with the study team.
Eligibility
Official eligibility criteria
Inclusion Criteria: * Age 18 years or older (no upper age limit) * Optimal medical therapy for heart failure by current guidelines * Class IIa or IIb guideline-based indication for CRT-D implant in RBBB patients, including one of the following: * New York Heart Association (NYHA) class II HF symptoms, LVEF ≤ 30% and QRS≥ 150 ms (IIb); OR * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration ≥ 150 ms (IIa); OR * NYHA class III-IV a HF, LVEF ≤ 35%, and QRS duration 120-149 ms (IIb) Exclusion Criteria: * Unable to obtain most recent imaging data from echocardiogram within 1 year prior to date of randomization * Left bundle branch block (LBBB) or intraventricular conduction delay (IVCD) ECG morphology * Unable or unwilling to follow study protocol * Less than 12 months life expectancy at consent * Pregnancy or planned pregnancy during duration of the study * On heart transplant list or likely to undergo heart transplant
Study sites (14)
AZ
- University of Arizona · Phoenix, AZ 85006Mathew Freeman · Study contactRoderick Tung · Principal investigatorMore trials in Phoenix
CA
- Cedars-Sinai Medical Center · Los Angeles, CA 90048Kelsey Duggin · Study contactEric Braunstein · Principal investigatorMore trials in Los Angeles
FL
- University of South Florida · Tampa, FL 33606Jacky He · Study contactBengt Herweg · Principal investigatorMore trials in Tampa
IL
- Northwestern Memorial Hospital · Chicago, IL 60611Madison Stat · Study contactNishant Verma · Principal investigatorMore trials in Chicago
- Rush University Medical Center · Chicago, IL 60612Samreen Ahmed · Study contactTimothy Larsen · Principal investigatorMore trials in Chicago
- University of Chicago · Chicago, IL 60637Shahram Sarrafi · Study contactGaurav Upadhyay · Principal investigatorMore trials in Chicago
NC
- Mission Health · Asheville, NC 28803Jordan Dalton · Study contactMichael Manogue · Principal investigatorMore trials in Asheville
NJ
- Valley Health System · Ridgewood, NJ 07450Sequoia Young · Study contactSuneet Mittal · Principal investigatorMore trials in Ridgewood
NY
- Weill Cornell Medical College · New York, NY 10021Penn Collins · Study contactJim Cheung · Principal investigatorMore trials in New York
- Mount Sinai Hospital · New York, NY 10029Shahryar Kamran · Study contactJacob Koruth · Principal investigatorMore trials in New York
PA
- University of Pennsylvania · Philadelphia, PA 19104Mary Gnap · Study contactRobert Schaller · Principal investigatorMore trials in Philadelphia
- Geisinger Wyoming Valley · Wilkes-Barre, PA 18711Grace Hughes · Study contactPugazhendhi Vijayaraman · Principal investigatorMore trials in Wilkes-Barre
VA
- Virginia Commonwealth University · Richmond, VA 23298Anya Baranova · Study contactKenneth Ellenbogen · Principal investigatorMore trials in Richmond
VT
- University of Vermont · Burlington, VT 05401Amy Henderson · Study contactMore trials in Burlington