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Valuation in Depressed Mood, Anhedonia, and Anxiety

Evaluating Overlap and Distinctiveness in Neurocomputational Loss and Reward Elements of the RDoC Matrix

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
25 Years to 50 Years
Sex
All sexes
Healthy volunteers
Not accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

Not stated in the study description — ask the study team about visits and procedures.

Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study looks at how people respond to rewards and losses. It explores how these responses are alike or different in people with low mood, anxiety, or anhedonia (trouble feeling pleasure).

This study examines how people respond to rewards and losses, and the extent to which these responses are linked or distinct among people experiencing depressed mood, anhedonia, and/or anxiety.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Have mood problems, anxiety, or trouble feeling pleasure that affect daily life.
  • Speak English fluently.
  • Can see a computer screen.
  • Can play simple computer games.

Who can't join

  • Have a history of seizures or stroke.
  • Had a head injury that caused you to pass out for more than 10 minutes.
  • Have a hormone disorder.
  • Had electroconvulsive therapy (ECT, a treatment using electrical pulses to the brain) within the past 5 years.
  • Have ever had chemotherapy (drug treatment) for cancer.
  • Are currently pregnant.
  • Have a condition or other reason that makes an MRI scan unsafe.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Inclusion Criteria: * mood, anxiety, or anhedonia symptoms that affect functioning; fluent in English; able to see computer display; able to perform simple computer games. Exclusion Criteria: * history of seizure disorder, stroke, or head injury with more than 10 minutes of unconsciousness; hormone disorder; electroconvulsive therapy within 5 years; history of chemotherapy for cancer; current pregnancy; contraindications to MRI

Study sites (1)

VA