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RECOVERS - Realigning Emotion and COgnition Via prEcision Regulation networkS

A Multiphase Program of Multimodal Computational Modeling and Hybrid Interventions Including EEG-Synchronized Transcranial Magnetic Stimulation and Cognitive Behavioral Therapy

Who can join

As published by the study on ClinicalTrials.gov. "Not stated" means the study hasn't said — ask the study team.

Age
18 Years to 65 Years
Sex
All sexes
Healthy volunteers
Accepted
Compensation
Not stated

Other requirements are listed under Eligibility below. Only the study team can confirm whether you can join.

What to expect

No one can promise a trial will help you personally — that is what the research is trying to find out.

What participation involves

  • Procedures mentioned: MRI scans, Questionnaires

Only what the study's summary and detailed description on ClinicalTrials.gov say. Time periods may describe the whole study or a part of it — ask the study team what applies to you.

Show the study's own words
  • "In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS)."
  • "To test this hypothesis, investigators utilize a novel integrated system that enables simultaneous functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and transcranial magnetic stimulation (TMS) to identify individualized stimulation parameters associated with optimal network coupling."
  • "Participants in interventional studies may also complete ecological momentary assessment (EMA) surveys via mobile devices to monitor mood, stress, and safety in real time."
Compensation
Not stated
  • Study-related exams and procedures are typically provided at no cost. This is how many trials work in general — confirm the details for this study with the study team.
  • Participants are monitored closely by the research team throughout the study.
  • Some participants may receive access to an investigational treatment, which is still being studied.
  • Your participation helps researchers learn whether this approach could help future patients.

About this study

In plain language

This study uses brain scans and recordings to learn how the brain handles feelings, attention, and memory. Some parts use magnetic pulses to study or change brain activity, thinking tasks, or brief talk therapy. It is for healthy adults and adults with depression, ages 18–65.

In this research study, investigators examine how brain activity changes during tests of emotional processing, attention, and memory using multimodal neuroimaging methods including electroencephalography (EEG), functional magnetic resonance imaging (fMRI), and functional near-infrared spectroscopy (fNIRS). Transcranial magnetic stimulation (TMS) is used to probe and modulate brain networks related to cognitive flexibility and emotion regulation. The study includes multiple related sub-studies involving healthy participants and participants with depression. Some study components focus on mechanistic modeling using non-therapeutic neurostimulation in healthy participants, while other components include interventional approaches such as individualized EEG-synchronized repetitive TMS (rTMS), cognitive tasks, and brief cognitive behavioral therapy (CBT) in participants with depression. Certain study components also evaluate CBT alone without TMS to assess behavioral intervention effects.

Compensation is read from the study's own description and may be missing — always confirm with the study team.

Eligibility

Who can join

  • Be 18–65 years old and speak English.
  • Be able to understand and agree to join the study.
  • Be willing and able to complete study activities.
  • Have a negative pregnancy test if you could become pregnant.
  • For Study 1: Be physically and mentally healthy, with no past mental health or brain or nerve disorders.
  • For Studies 2–4: Have a current diagnosis of major depression.
  • For Studies 2–4: Meet the study’s rules for how severe your depression is.
  • For Studies 2–4: Have no history of bipolar disorder or psychotic disorders, which can affect your sense of what is real.

Who can't join

  • Have a brain or nerve disorder, or a past disease of the brain or spinal cord.
  • Have had seizures or epilepsy, or take medicine that makes seizures more likely.
  • Have had a serious head injury or loss of consciousness.
  • Have metal implants or another reason you cannot safely have MRI brain scans or magnetic brain stimulation (TMS).
  • Have a substance use disorder, except one involving nicotine or caffeine.
  • Are pregnant or plan to become pregnant during the study.
  • For Study 1: Have any current or past mental health diagnosis, or cannot complete study activities.
  • For Studies 2–4: Are in another trial that tests a treatment, or have a condition that makes participation unsafe or prevents you from finishing study activities.

Simplified for readability. The official criteria below are what the study team uses.

Official eligibility criteria

Study 1 (Healthy Participants) Inclusion Criteria: * Age 18-65 years * Medically and psychiatrically healthy with no history of psychiatric or neurological disorders * English-speaking * Capacity to provide informed consent * Willingness and ability to complete study procedures * Negative pregnancy test for participants of childbearing potential Exclusion Criteria: * Any current or past psychiatric diagnosis * Neurological disorders or history of central nervous system disease * History of seizure or epilepsy or use of medications that lower seizure threshold * Significant head injury or loss of consciousness * Implanted metal or contraindications to MRI or TMS * Substance use disorder (excluding nicotine or caffeine) * Pregnancy or plans to become pregnant during study participation * Inability to complete study procedures Studies 2, 3, and 4 (Participants With Depression) Inclusion Criteria: * Age 18-65 years * Current diagnosis of Major Depressive Disorder (MDD) * Depression severity consistent with study criteria (e.g., HAM-D ≥17) * No history of psychotic or bipolar disorders * English-speaking * Capacity to provide informed consent * Willingness and ability to complete study procedures * Negative pregnancy test for participants of childbearing potential Exclusion Criteria: * Neurological disorders or history of central nervous system disease * History of seizure or epilepsy or use of medications that lower seizure threshold * Significant head injury or loss of consciousness * Implanted metal or contraindications to MRI or TMS * Substance use disorder (excluding nicotine or caffeine) * Current participation in another interventional clinical trial * Pregnancy or plans to become pregnant during study participation * Any condition that would interfere with safe participation or completion of study procedures

Study sites (1)

SC